Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling - Wikidata - awgldk - TriplyDB

Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling

Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling

http://www.wikidata.org/entity/Q35662291

about

Ubc13: the Lys63 ubiquitin chain building machine Untangling the Manganese-α-Synuclein Web Parkin Regulation and Neurodegenerative Disorders Oxidative stress and Parkinson's disease Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.Regulators of mitochondrial dynamics in cancer.Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Neuropathology of α-synuclein propagation and braak hypothesis.Mitochondrial fission and fusion in secondary brain damage after CNS insults.Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease Ubiquitin and Parkinson's disease through the looking glass of genetics.Looking at the recent advances in understanding α-synuclein and its aggregation through the proteoform prism.αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson's disease.Upregulation of autophagy-related gene 5 protects dopaminergic neurons in a zebrafish model of Parkinson's disease.Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.Let's make microglia great again in neurodegenerative disorders.Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.Beyond Deubiquitylation: USP30-Mediated Regulation of Mitochondrial Homeostasis.Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.Parkinson's Disease Skin Fibroblasts Display Signature Alterations in Growth, Redox Homeostasis, Mitochondrial Function, and Autophagy.Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies.The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.

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P2860

Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling

http://www.wikidata.org/entity/Q35662291

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Convergence of Parkin, PINK1, ...... drial Morphological Remodeling

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Convergence of Parkin, PINK1, ...... drial Morphological Remodeling

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type

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Convergence of Parkin, PINK1, ...... drial Morphological Remodeling

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Convergence of Parkin, PINK1, ...... drial Morphological Remodeling

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Convergence of Parkin, PINK1, ...... drial Morphological Remodeling

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Convergence of Parkin, PINK1, ...... drial Morphological Remodeling

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JBC.M114.634063

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Convergence of Parkin, PINK1, ...... drial Morphological Remodeling

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Anna E West

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Chun-Hsiang Lai

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Dennis Chou

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Jin Yan

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Kah-Leong Lim

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Kristi L Norris

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Liang-Fu Chen

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Meghan Kapur

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Peter J Shaughnessy

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Rui Hao

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins.

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