Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. - Wikidata - awgldk - TriplyDB

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

http://www.wikidata.org/entity/Q36731585

about

Progeria: a rare genetic premature ageing disorder mTOR is a key modulator of ageing and age-related disease Skeletal Muscle Laminopathies: A Review of Clinical and Molecular Features Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond Mitochondrial Quality Control and Muscle Mass Maintenance When lamins go bad: nuclear structure and disease Mouse models of laminopathies Nuclear lamins and oxidative stress in cell proliferation and longevity The nuclear envelope: an intriguing focal point for neurogenetic disease Genetic Variations Leading to Familial Dilated Cardiomyopathy Disrupted autophagy undermines skeletal muscle adaptation and integrity Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy Titin-truncating variants affect heart function in disease cohorts and the general population.Oxidative stress and antioxidant response in fibroblasts from Werner and atypical Werner syndromes.Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.LMNA Sequences of 60,706 Unrelated Individuals Reveal 132 Novel Missense Variants in A-Type Lamins and Suggest a Link between Variant p.G602S and Type 2 Diabetes From rapalogs to anti-aging formula.The Inhibitory Effect of WenxinKeli on H9C2 Cardiomyocytes Hypertrophy Induced by Angiotensin II through Regulating Autophagy Activity.In silico investigation of potential mTOR inhibitors from traditional Chinese medicine for treatment of Leigh syndrome The intriguing regulators of muscle mass in sarcopenia and muscular dystrophy.Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.Rapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics GENETIC CAUSES OF DILATED CARDIOMYOPATHY.Gerosuppression in confluent cells.Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Zebrafish ambra1a and ambra1b knockdown impairs skeletal muscle development.MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis.Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain Fasting levels of hepatic p-S6 are increased in old mice

P2860

Q24564144-1BF14B76-C388-462B-AA0E-075347E00E77 Q24610741-B0316174-587D-4C72-8A86-EE1290572385 Q26741163-882D7DC9-A451-4650-8316-CE91AC7129B6 Q26747742-F68D6369-C4F7-4F2C-A57C-2A4648486689 Q26751462-FFC84EDB-F4DF-4798-844B-DC5382131670 Q26770420-03C97F37-91DF-433D-B016-9CB19970E9A5 Q26827624-C48ADCDB-810E-44FA-A422-6F3107966709 Q26829927-B1D48F47-EBC5-41DE-8F6C-F03F2203304C Q27003105-47448420-00A8-4C44-BB0E-E3C4264A96E3 Q27006719-6503B9D2-D6E2-409C-A390-89142EB7FB46 Q28067043-A94FDB86-DC4D-4F70-8596-A9C49932453A Q28077297-755F5520-7EA5-4A3A-B7DC-D3E786458672 Q28267272-CCF11DD3-0CBD-4806-A36B-F4AEE9EE5A12 Q28271425-95CEE23C-C7A6-418B-9275-8835B8E33BBE Q28275005-B8824AC8-1F07-434B-8681-283B16BCC040 Q28276378-349D561A-C4BA-4725-AF64-EA4D1365E481 Q28307873-845AF08C-6EEC-4D90-88D1-EB6A0F1D2E02 Q28504504-F5612B4F-0B35-4CF4-9CDD-A4B2DB8FC02E Q28547400-7F963364-B303-4218-9EBD-50AD7C053229 Q28547713-B3A80316-3DF8-4729-9367-EF52A774D287 Q30833466-423CA0B2-E567-4E1E-AEBC-7DC8665544D1 Q33577727-E5E11894-25D4-4C2C-8D15-2204A8C385D2 Q33657305-796AAFB6-3921-4910-8A9C-F1069E121793 Q33749391-2153189B-D71D-48AA-B86C-537FB8745915 Q33799816-490890A7-87CB-4F58-85FE-8D2A28D543C2 Q33829205-0CA42F24-B557-45C0-9F72-C03E631EB496 Q33868133-396A91EC-6B07-4E4E-9EDF-E6D70AF5FDFE Q33876312-0117A54D-1A9F-4B6F-9A08-FB387225EA44 Q34106342-0EA8E75D-CFF8-4D6C-B9F8-1122E18B3A82 Q34170669-15BBF557-6804-4728-A317-EC4633E426D8 Q34520717-205888B0-EB92-4C1C-B9B1-5416BD9D0C24 Q34881335-66903247-8565-4B20-9D79-05CE5BF113B4 Q34982499-1054012D-DED4-44C5-AD59-7EECB3502AFB Q35080619-C1CDF984-CC64-456B-BE7B-9D4723BF2DC3 Q35149607-3BDF68C7-E53F-49B5-90CA-01FFC88F152B Q35186864-52B8F23C-F5D6-4EFC-A584-A657CEE89530 Q35579292-064E8CEF-20D3-45C5-A63E-55C77D2A9BDB Q35877085-B809B08D-3624-46C2-9D8A-B69BE179186D Q36140656-9EE8EFB9-F306-4870-8DED-97E4BEDDFA2E Q36182265-32ECB7FD-6C52-437F-AEDF-5D7A71DEDC53

P2860

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

http://www.wikidata.org/entity/Q36731585

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Rapamycin reverses elevated mT ...... unction, and extends survival.

@ast

Rapamycin reverses elevated mT ...... unction, and extends survival.

@en

type

label

Rapamycin reverses elevated mT ...... unction, and extends survival.

@ast

Rapamycin reverses elevated mT ...... unction, and extends survival.

@en

prefLabel

Rapamycin reverses elevated mT ...... unction, and extends survival.

@ast

Rapamycin reverses elevated mT ...... unction, and extends survival.

@en

P1433

Q36731585-5B1202DD-52B9-43A6-9118-A99C544FCB60

P1476

Q36731585-1F93E2C2-98BE-451B-87C3-A92E4FEB7447

P2093

Q36731585-0F828FD8-7B17-4988-A526-7CC9C42AAFD6

Q36731585-1B1DCDCC-890B-42EA-93C6-9F172B05CF50

Q36731585-32D177D1-D5CB-419E-B655-8281A5A0E442

Q36731585-3C4FC5B8-1365-4898-A17A-FDC5962E95AB

Q36731585-4D9609FF-0258-48E2-B925-3FB81874DBCA

Q36731585-5251D6C3-2121-4D57-9014-73EBDFB6BB8D

Q36731585-5C34BA4D-710D-4C74-A3C0-029927E48937

Q36731585-6EF0BC12-77C2-41E0-B57B-AB6109176D01

Q36731585-9D13F614-83DD-4CCD-87CF-B3232A5534AF

Q36731585-BB4F4135-9553-4A76-9EBE-9D1D9A13B16E

P2860

Q36731585-03A60B85-58A1-46F4-84D8-823DEFEB451F

Q36731585-0D3CCAF2-921F-4401-9684-DF5B9C792A04

Q36731585-0DABBD51-6065-476E-A53C-31478BFD6DEF

Q36731585-0E6733BC-4F9C-425F-BF6A-69D79509022D

Q36731585-1290F08C-F41F-4EE4-8F1E-E1DAC8F14A1B

Q36731585-148B7EE4-8B79-49B7-B77F-4A80F379191B

Q36731585-1873C95D-1014-415B-A38A-D3C0400FE213

Q36731585-1F18C879-DA90-4927-938F-0760AAA74B41

Q36731585-2376FB0E-5A18-4A9A-A843-63B99B7F3968

Q36731585-23E60989-309F-4068-8B1F-F110045B9CBE

P304

Q36731585-2B288A7E-C681-481C-8D6B-7972BCCF1712

P31

Q36731585-8A54B575-6F30-44F5-A382-D25A81456EE0

P356

Q36731585-EF977A9F-DA97-4CB3-8666-C9F2C275B8EB

P407

Q36731585-B2BC0FA3-73A9-4F71-852D-21D1F3ADA75A

P433

Q36731585-C518A094-8EB8-46BC-9DE3-8F17BDBEC0F7

P478

Q36731585-DF0A6B6B-703A-454E-88FC-C0B728057524

P50

Q36731585-08201372-336F-4899-8DB6-6C566B05591B

Q36731585-34DDE3CA-E37A-4162-91EA-4DFA662AA893

Q36731585-55B7ADF3-760C-4BA4-ABC6-A5F532151C3D

P577

Q36731585-906F83FE-A793-4582-98F4-94E97433CFBD

P5875

Q36731585-FEA922CA-716E-4FEA-AB06-4D9E5F5AA606

P698

Q36731585-E46DAC96-53B1-442A-8991-C62E43DF92A1

P932

Q36731585-B55996EE-512E-48EE-9044-D4FC4B48274A

P356

SCITRANSLMED.3003802

P1433

Science Translational Medicine

P1476

Rapamycin reverses elevated mT ...... function, and extends survival

@en

P2093

Chen-Yu Liao

http://www.w3.org/2001/XMLSchema#string

Elroy H An

http://www.w3.org/2001/XMLSchema#string

Fresnida J Ramos

http://www.w3.org/2001/XMLSchema#string

Katherine H Schreiber

http://www.w3.org/2001/XMLSchema#string

Matt Kaeberlein

http://www.w3.org/2001/XMLSchema#string

Michael G Garelick

http://www.w3.org/2001/XMLSchema#string

Randy Strong

http://www.w3.org/2001/XMLSchema#string

Steven C Chen

http://www.w3.org/2001/XMLSchema#string

Vivian L MacKay

http://www.w3.org/2001/XMLSchema#string

Warren C Ladiges

http://www.w3.org/2001/XMLSchema#string

P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Guidelines for the use and interpretation of assays for monitoring autophagy

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

The TOR pathway comes of age

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse

P304

144ra103

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCITRANSLMED.3003802

http://www.w3.org/2001/XMLSchema#string

P407

P433

144

http://www.w3.org/2001/XMLSchema#string

P478

4

http://www.w3.org/2001/XMLSchema#string

P50

Brian K Kennedy

P S Rabinovitch

P577

2012-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230574106

http://www.w3.org/2001/XMLSchema#string

P698

22837538

http://www.w3.org/2001/XMLSchema#string

P932

3613228

http://www.w3.org/2001/XMLSchema#string