Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
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Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotauNeuroprotection mediated by inhibition of calpain during acute viral encephalitisTHE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASECysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Spines, plasticity, and cognition in Alzheimer's model miceLysosome and calcium dysregulation in Alzheimer's disease: partners in crimeThe cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activityGenetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor proteinMolecular mechanisms of cognitive dysfunction following traumatic brain injuryAnnotation of functional variation in personal genomes using RegulomeDBCalpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type micePhospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.Caloric restriction improves diabetes-induced cognitive deficits by attenuating neurogranin-associated calcium signaling in high-fat diet-fed miceCalcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceCalpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes.Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer diseaseTau phosphorylation and μ-calpain activation mediate the dexamethasone-induced inhibition on the insulin-stimulated Akt phosphorylation.Endocannabinoids prevent β-amyloid-mediated lysosomal destabilization in cultured neurons.Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model.The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity.UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient miceNanomedicine strategies for treatment of secondary spinal cord injury.Synaptic therapy in Alzheimer's disease: a CREB-centric approach.Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.Neuroprotective strategies against calpain-mediated neurodegeneration.Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices.Chemical and Structural Aspects of Ebola Virus Entry Inhibitors.Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice.Misexpression screen delineates novel genes controlling Drosophila lifespanCalpain-mediated cleavage of DARPP-32 in Alzheimer's disease.Rodent models for Alzheimer's disease drug discovery.Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents.Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia.
P2860
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P2860
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Inhibition of calpains improve ...... se model of Alzheimer disease.
@ast
Inhibition of calpains improve ...... se model of Alzheimer disease.
@en
type
label
Inhibition of calpains improve ...... se model of Alzheimer disease.
@ast
Inhibition of calpains improve ...... se model of Alzheimer disease.
@en
prefLabel
Inhibition of calpains improve ...... se model of Alzheimer disease.
@ast
Inhibition of calpains improve ...... se model of Alzheimer disease.
@en
P2093
P2860
P50
P356
P1476
Inhibition of calpains improve ...... se model of Alzheimer disease.
@en
P2093
Ariel Hidalgo
Fabrizio Trinchese
Hisako Yamaguchi
Hong Zhang
Narihiko Yoshii
Ralph A Nixon
Shumin Liu
Stephen D Schmidt
P2860
P304
P356
10.1172/JCI34254
P407
P577
2008-08-01T00:00:00Z