Direct and selective small-molecule activation of proapoptotic BAX - Wikidata - awgldk - TriplyDB

Direct and selective small-molecule activation of proapoptotic BAX

Direct and selective small-molecule activation of proapoptotic BAX

http://www.wikidata.org/entity/Q36741892

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Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 Direct Activation of Bax Protein for Cancer Therapy Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.Small-molecule Bax agonists for cancer therapy.Targeting nucleocytoplasmic transport in cancer therapy Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions Small molecules reveal an alternative mechanism of Bax activation.The BCL-2 protein family, BH3-mimetics and cancer therapy.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members Direct activation of full-length proapoptotic BAK Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3 Mitochondria: gatekeepers of response to chemotherapy Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation.Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells.Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis.Molecular simulations of drug-receptor complexes in anticancer research.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.Many players in BCL-2 family affairs.Apoptosis inducers in chronic lymphocytic leukemia.Mitochondrial apoptosis: killing cancer using the enemy within.Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies.New dimension in therapeutic targeting of BCL-2 family proteins.Targeting Programmed Cell Death Using Small-Molecule Compounds to Improve Potential Cancer Therapy.Physiological and Pharmacological Control of BAK, BAX, and Beyond.An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.Low probability activation of Bax/Bak can induce selective killing of cancer cells by generating heterogeneity in apoptosis.Chemical biologists rush to San Francisco for the ICBS.Apoptosis therapy: driving cancers down the road to ruin.The BCL-2 arbiters of apoptosis and their growing role as cancer targets.Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2).Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

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P2860

Direct and selective small-molecule activation of proapoptotic BAX

http://www.wikidata.org/entity/Q36741892

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Direct and selective small-molecule activation of proapoptotic BAX

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Direct and selective small-molecule activation of proapoptotic BAX

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type

label

Direct and selective small-molecule activation of proapoptotic BAX

@ast

Direct and selective small-molecule activation of proapoptotic BAX

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prefLabel

Direct and selective small-molecule activation of proapoptotic BAX

@ast

Direct and selective small-molecule activation of proapoptotic BAX

@en

P1433

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P1433

Nature Chemical Biology

P1476

Direct and selective small-molecule activation of proapoptotic BAX

@en

P2093

Denis E Reyna

http://www.w3.org/2001/XMLSchema#string

Elizaveta S Leshchiner

http://www.w3.org/2001/XMLSchema#string

Joseph A Bellairs

http://www.w3.org/2001/XMLSchema#string

Loren D Walensky

http://www.w3.org/2001/XMLSchema#string

P2860

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

A stapled BID BH3 helix directly binds and activates BAX

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

BID: a novel BH3 domain-only death agonist

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

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P304

639-645

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scholarly article

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10.1038/NCHEMBIO.995

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7

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8

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Evripidis Gavathiotis

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2012-05-27T00:00:00Z

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225064051

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22634637

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3617124

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