Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway
about
Targeting Protein-Protein Interactions in the HIF SystemPHD2: from hypoxia regulation to disease progressionThe role of PHD2 mutations in the pathogenesis of erythrocytosis.Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensingHuman high-altitude adaptation: forward genetics meets the HIF pathway.Identification of prolyl hydroxylation modifications in mammalian cell proteins.RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect.Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells.O2 sensing, mitochondria and ROS signaling: The fog is liftingThe Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin AThe Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel-Lindau-dependent pathway.Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans.Novel interaction between CCR4 and CAF1 in rice CCR4-NOT deadenylase complex.Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease.
P2860
Q26753176-CDFB2F76-0815-429C-835B-C9F96186D010Q28069316-367488F7-BF73-40C8-A6BC-3A4A0D1C0A27Q28598099-65DE85DF-83E2-4807-9EDC-071C751165EAQ33652089-0E94BE6E-5FE7-4D04-AE67-38AE598E7B92Q34360748-81C1B2F9-FF63-4A7F-89CC-F5DF7A4AFC27Q35627753-C33D57E9-BA78-444B-9C66-5D2A6B38B432Q36026989-1AE85B63-A8A1-4D2F-8F59-92EDBDF74919Q36171969-EF3776BF-01EE-407C-907A-4781B6357171Q36518627-98D0A091-8C03-4126-9F33-EEDBB6D4808BQ36569981-F21C4B30-EAA4-496C-8706-A0EEB325D718Q36724229-BFE4FDDC-1B53-4EE0-9EB7-769ECEC32B9DQ37224157-98DD99A5-1B69-4FAA-9BDC-BB733FA56AD5Q37333699-C9687882-DFE8-416D-A46B-D6FA26E8B291Q39051696-37B6A97B-1808-469B-A9E4-03E532620FA2Q43093361-CDD44B2A-8837-46CF-B94C-197F113FEBFFQ51420794-842BFD96-81F5-4681-A4F6-78A78327D525Q51767924-13032AFD-47BD-4DB4-B60B-9F00A6748EBD
P2860
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Prolyl hydroxylase domain prot ...... heat shock protein 90 pathway
@ast
Prolyl hydroxylase domain prot ...... heat shock protein 90 pathway
@en
type
label
Prolyl hydroxylase domain prot ...... heat shock protein 90 pathway
@ast
Prolyl hydroxylase domain prot ...... heat shock protein 90 pathway
@en
prefLabel
Prolyl hydroxylase domain prot ...... heat shock protein 90 pathway
@ast
Prolyl hydroxylase domain prot ...... heat shock protein 90 pathway
@en
P2093
P2860
P356
P1476
Prolyl hydroxylase domain prot ...... heat shock protein 90 pathway
@en
P2093
Daisheng Song
Katherine J Heaton-Johnson
Lin-Sheng Li
Patrick R Arsenault
Stephen R Master
P2860
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
P304
P356
10.1074/JBC.M112.440552
P407
P50
P577
2013-02-14T00:00:00Z