Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.
about
Human TSH receptor ligands as pharmacological probes with potential clinical applicationThyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activationA small molecule inverse agonist for the human thyroid-stimulating hormone receptorNovel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptorThe hinge region of human thyroid-stimulating hormone (TSH) receptor operates as a tunable switch between hormone binding and receptor activation.Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structureBlocking type TSH receptor antibodies.Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells.The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunizationEvidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' diseaseA monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domainNew horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics.Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies.
P2860
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P2860
Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification of key amino ac ...... ist and antagonist properties.
@ast
Identification of key amino ac ...... ist and antagonist properties.
@en
type
label
Identification of key amino ac ...... ist and antagonist properties.
@ast
Identification of key amino ac ...... ist and antagonist properties.
@en
prefLabel
Identification of key amino ac ...... ist and antagonist properties.
@ast
Identification of key amino ac ...... ist and antagonist properties.
@en
P2860
P356
P1433
P1476
Identification of key amino ac ...... ist and antagonist properties.
@en
P2093
Chun-Rong Chen
Sandra M McLachlan
P2860
P304
P356
10.1210/EN.2008-0207
P407
P577
2008-04-03T00:00:00Z