Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms. - Wikidata - awgldk - TriplyDB

Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.

Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.

http://www.wikidata.org/entity/Q36761745

about

Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair DNA polymerase γ and disease: what we have learned from yeast Serine, glycine and one-carbon units: cancer metabolism in full circle The conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2 Transgenic overexpression of ribonucleotide reductase improves cardiac performance.Metabolic genes in cancer: their roles in tumor progression and clinical implications Multiphoton microscopy as a diagnostic imaging modality for lung cancer.Nucleotide metabolism, oncogene-induced senescence and cancer.Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.Ribonucleotide reductase large subunit M1 predicts poor survival due to modulation of proliferative and invasive ability of gastric cancer.Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images.Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype p53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung.AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility.Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis.Cyclins and cell cycle control in cancer and disease.BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase Genetic variation and DNA replication timing, or why is there late replicating DNA?Molecular biomarkers for predicting chemotherapy response in lung cancer.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.Deoxyribonucleotide metabolism, mutagenesis and cancer.P53 suppresses ribonucleotide reductase via inhibiting mTORC1.Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.A Critical Balance: dNTPs and the Maintenance of Genome Stability Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.Cell-based delivery of dATP via gap junctions enhances cardiac contractility.Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses.Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.Dynamic Control of dNTP Synthesis in Early Embryos.Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease.Identification of key candidate genes and small molecule drugs in cervical cancer by bioinformatics strategy

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P2860

Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.

http://www.wikidata.org/entity/Q36761745

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2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Broad overexpression of ribonu ...... ically induces lung neoplasms.

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Broad overexpression of ribonu ...... ically induces lung neoplasms.

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type

label

Broad overexpression of ribonu ...... ically induces lung neoplasms.

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Broad overexpression of ribonu ...... ically induces lung neoplasms.

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Broad overexpression of ribonu ...... ically induces lung neoplasms.

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Cancer Research

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Broad overexpression of ribonu ...... ically induces lung neoplasms.

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Alexander Yu Nikitin

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Eric Alani

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Houchun Liu

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Jennifer A Surtees

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Jennifer L Page

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Robert S Weiss

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Roderick Bronson

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Sarah Lagedrost

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Xia Xu

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Young Lu

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P2860

Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme

Free radicals in the physiological control of cell function

A ribonucleotide reductase gene is a transcriptional target of p53 and p73

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Pathway correcting DNA replication errors in Saccharomyces cerevisiae

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair

Ribonucleotide reductases

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

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