Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.
about
Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patientsCyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repairDNA polymerase γ and disease: what we have learned from yeastSerine, glycine and one-carbon units: cancer metabolism in full circleThe conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit M2Transgenic overexpression of ribonucleotide reductase improves cardiac performance.Metabolic genes in cancer: their roles in tumor progression and clinical implicationsMultiphoton microscopy as a diagnostic imaging modality for lung cancer.Nucleotide metabolism, oncogene-induced senescence and cancer.Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.Ribonucleotide reductase large subunit M1 predicts poor survival due to modulation of proliferative and invasive ability of gastric cancer.Growth pattern analysis of murine lung neoplasms by advanced semi-automated quantification of micro-CT images.Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking statusEndogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotypep53R2 expression as a prognostic biomarker in early stage non-small cell lung cancerTargeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.Multiphoton microscopy and microspectroscopy for diagnostics of inflammatory and neoplastic lung.AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility.Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis.Cyclins and cell cycle control in cancer and disease.BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductaseGenetic variation and DNA replication timing, or why is there late replicating DNA?Molecular biomarkers for predicting chemotherapy response in lung cancer.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.Deoxyribonucleotide metabolism, mutagenesis and cancer.P53 suppresses ribonucleotide reductase via inhibiting mTORC1.Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.A Critical Balance: dNTPs and the Maintenance of Genome StabilitySuppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.Cell-based delivery of dATP via gap junctions enhances cardiac contractility.Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses.Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.Dynamic Control of dNTP Synthesis in Early Embryos.Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease.Identification of key candidate genes and small molecule drugs in cervical cancer by bioinformatics strategy
P2860
Q21144211-9230B0B2-8B19-402C-ABE0-DD6DC107263CQ24336569-DEB17A01-8A6A-4E56-B4E5-0E9F994B4957Q26825324-DD485D6D-82E2-4E9C-8287-037CFA75608AQ26828610-3BA9E318-6C4D-4536-8E5F-A54774327AE8Q30355772-BB23B6EF-840A-42B3-A799-FAE0D7F80BE7Q30538819-959473FD-FE13-4CBD-9619-588B1E3A7C69Q33772469-4290DDF3-F138-43F9-AB65-61FBAF5434A9Q33824839-598C5F63-1AC4-42B1-962F-6E8A8B8DE302Q33969333-90FF8663-266A-4689-80EB-9CEDC4BAC376Q34401495-5B128AD7-0940-4FCC-9DD6-36AC52FB94ADQ34906454-3B7FC673-CBDF-40A9-8ECE-973079688833Q35078219-40D31893-A1A9-47C8-BEB4-F01BDCBA6550Q35293714-BE6180C0-58B5-45D0-AEDC-1D193D2EB623Q35637007-79D726FB-CC0D-41FB-9ED0-A7891A5A218FQ35760007-ADC01D27-B3BC-49A1-90AD-DAB222ABFC91Q36216571-2E0DDAA8-85E4-4309-8CF2-5D1318599BECQ36353167-6ADD59F4-D319-4B53-9EB4-39E43AE8110DQ36684353-9F7CBDC0-F916-4068-A3A0-AB74989962BFQ36700259-77662517-BA66-4D4D-8716-B61D2B8D3DF9Q36756838-7676803B-0A6D-4FC4-BAAB-5C0AB7DE0099Q36781128-7D3833AE-C306-49DC-9FD6-3E07C9997E01Q36796438-13713E2C-CEC1-4916-AF85-65B49C982F59Q37423731-D7702347-5EF4-4A59-9E22-D736C17176D2Q37459066-7E6F8D0A-55C4-4D65-8328-5C99F9E29635Q37948969-8BA9968A-FE8F-44E9-BC14-7CE22CAFD947Q38089839-D23130F5-5741-471A-8E32-CF1B18C10E43Q38218536-A2631977-A04A-4242-9206-94E4CFCA2A46Q38271431-8720DE8B-FCFE-4541-80FB-77AD470AE6F3Q38572102-1BF26BAE-8B65-4B62-9B0B-D573A03D5147Q38784684-D9CF6D27-ABA6-4389-B548-CDD894349D30Q38950646-B88C1ABA-EE29-445B-A3BD-DE9E62976C08Q39113436-6D8D66F6-AADD-41D9-B289-9955C70655AAQ39170489-BA1829F2-30A5-4E08-B7FB-AF12D74801C3Q41375244-FDAC78A2-77A8-43D4-93AE-240320FC5C5AQ41919532-5F7F3DB7-7C5B-4D2F-891F-284725283242Q47156483-082074C5-901B-44D5-8F37-4B346AEA4FC6Q47891068-02ECCC04-7C22-4A14-AD33-0C9D982C4645Q53688741-5C4933B2-C0A2-46C4-9528-B5D7607BCBD9Q57075019-7CA8C81C-0D9E-4B93-8DC4-1E24D1D525E9
P2860
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Broad overexpression of ribonu ...... ically induces lung neoplasms.
@ast
Broad overexpression of ribonu ...... ically induces lung neoplasms.
@en
type
label
Broad overexpression of ribonu ...... ically induces lung neoplasms.
@ast
Broad overexpression of ribonu ...... ically induces lung neoplasms.
@en
prefLabel
Broad overexpression of ribonu ...... ically induces lung neoplasms.
@ast
Broad overexpression of ribonu ...... ically induces lung neoplasms.
@en
P2093
P2860
P1433
P1476
Broad overexpression of ribonu ...... ically induces lung neoplasms.
@en
P2093
Alexander Yu Nikitin
Eric Alani
Houchun Liu
Jennifer A Surtees
Jennifer L Page
Robert S Weiss
Roderick Bronson
Sarah Lagedrost
P2860
P304
P356
10.1158/0008-5472.CAN-07-5873
P407
P577
2008-04-01T00:00:00Z