Targeting of hexokinase 1 to liver and hepatoma mitochondria
about
Targeting of a germ cell-specific type 1 hexokinase lacking a porin-binding domain to the mitochondria as well as to the head and fibrous sheath of murine spermatozoaThe structure of mammalian hexokinase-1Prediction of protein orientation upon immobilization on biological and nonbiological surfacesA developmentally regulated, neuron-specific splice variant of the variable subunit Bbeta targets protein phosphatase 2A to mitochondria and modulates apoptosisA mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicineCharacterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity.Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.A mutation in an alternative untranslated exon of hexokinase 1 associated with hereditary motor and sensory neuropathy -- Russe (HMSNR).Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins.VDAC1: from structure to cancer therapy.Pathophysiological consequences of TAT-HKII peptide administration are independent of impaired vascular function and ensuing ischemia.CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotectionMitochondrial ion channels as oncological targets.Mitochondrial channels: ion fluxes and more.The role of hexokinase in cardioprotection - mechanism and potential for translation.Hexokinases and cardioprotection.Identification of a mitochondrial-binding site on the N-terminal end of hexokinase IIMitochondrial Ca2+ and regulation of the permeability transition pore.Two-color STED microscopy reveals different degrees of colocalization between hexokinase-I and the three human VDAC isoforms.Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line.Characterization of porin isoforms expressed in tumor cells.A novel NH(2)-terminal, nonhydrophobic motif targets a male germ cell-specific hexokinase to the endoplasmic reticulum and plasma membrane.Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability.AKAP350C targets to mitochondria via a novel amphipathic alpha helical domain.Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin.VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis.Targeting Mitochondrial Ion Channels to Fight Cancer
P2860
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P2860
Targeting of hexokinase 1 to liver and hepatoma mitochondria
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Targeting of hexokinase 1 to liver and hepatoma mitochondria
@ast
Targeting of hexokinase 1 to liver and hepatoma mitochondria
@en
type
label
Targeting of hexokinase 1 to liver and hepatoma mitochondria
@ast
Targeting of hexokinase 1 to liver and hepatoma mitochondria
@en
prefLabel
Targeting of hexokinase 1 to liver and hepatoma mitochondria
@ast
Targeting of hexokinase 1 to liver and hepatoma mitochondria
@en
P2093
P2860
P356
P1476
Targeting of hexokinase 1 to liver and hepatoma mitochondria
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.1.202
P407
P577
1992-01-01T00:00:00Z