Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder.
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The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox proteinRetroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cellsImpaired DNA replication within progenitor cell pools promotes leukemogenesis.Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.Acute side effects of homologous interleukin-3 in rhesus monkeys.Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells.Expression of human alpha-globin and mouse/human hybrid beta-globin genes in murine hemopoietic stem cells transduced by recombinant retroviruses.Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.Mechanisms of transformation by the BCR/ABL oncogene.Autocrine stimulation by erythropoietin and autonomous growth of human erythroid leukemic cells in vitroRecent advances in the molecular and cellular biology of chronic myeloid leukaemia: lessons to be learned from the laboratory.Interleukin-3.Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cellsProduction of human glucocerebrosidase in mice after retroviral gene transfer into multipotential hematopoietic progenitor cells.Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in miceOverexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease.Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responsesIsolation of new oncogenic forms of the murine c-fms gene.Transgenic mice in the study of cytokine functionTyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.Disease states induced by hemopoietic growth factor excess: their implications in medicine.Hyperexpression of interleukin-7 is not necessary or sufficient for transformation of a pre-B lymphoid cell line.High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library.Ectopic lymphokine gene expression in human peripheral blood lymphocytes in vivo.Independently arising macrophage mutants dissociate growth factor-regulated survival and proliferation.Leukemia initiated by hemopoietic stem cells expressing the v-abl oncogene.Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells.Animal models for the biological effects of continuous high cytokine levels.Why clinicians should be interested in interleukin-3.Gene transfer into hemopoietic stem cells using retroviral vectors.Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression.Gene transfer into hematopoietic progenitor and stem cells: progress and problems.A single point mutation at the 3'-untranslated region of Ran mRNA leads to profound changes in lipopolysaccharide endotoxin-mediated responses.Development of a high-titer retrovirus producer cell line and strategies for retrovirus-mediated gene transfer into rhesus monkey hematopoietic stem cells.Sustained elevation of neutrophils in rats induced by lentivirus-mediated G-CSF delivery.Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer.
P2860
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P2860
Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Retrovirus-mediated transfer a ...... a myeloproliferative disorder.
@ast
Retrovirus-mediated transfer a ...... a myeloproliferative disorder.
@en
type
label
Retrovirus-mediated transfer a ...... a myeloproliferative disorder.
@ast
Retrovirus-mediated transfer a ...... a myeloproliferative disorder.
@en
prefLabel
Retrovirus-mediated transfer a ...... a myeloproliferative disorder.
@ast
Retrovirus-mediated transfer a ...... a myeloproliferative disorder.
@en
P2093
P2860
P356
P1476
Retrovirus-mediated transfer a ...... a myeloproliferative disorder.
@en
P2093
A W Nienhuis
C E Dunbar
D M Bodine
S Ruscetti
P2860
P304
P356
10.1128/MCB.9.2.798
P407
P577
1989-02-01T00:00:00Z