Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. - Wikidata - awgldk - TriplyDB

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

http://www.wikidata.org/entity/Q36776382

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Strategically targeting MYC in cancer Advances in sarcoma diagnostics and treatment mTOR: An attractive therapeutic target for osteosarcoma?The HIV protease inhibitor, nelfinavir, as a novel therapeutic approach for the treatment of refractory pediatric leukemia.BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma.The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs.Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations.The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition.BET inhibitors: a novel epigenetic approach.Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma.BET Proteins: An Approach to Future Therapies in Transplantation.Molecular Pathways: Targeting the PI3K Pathway in Cancer-BET Inhibitors to the Rescue Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway.Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors.Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.Bisphosphonate-Functionalized Hydroxyapatite Nanoparticles for the Delivery of the Bromodomain Inhibitor JQ1 in the Treatment of Osteosarcoma.Targeting LncRNA-MALAT1 suppresses the progression of osteosarcoma by altering the expression and localization of β-catenin.The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling.Reactivation of endogenous retroviral elements via treatment with DNMT- and HDAC-inhibitors.Genome-wide transcriptional analysis of BRD4-regulated genes and pathways in human glioma U251 cells.The natural sweetener metabolite steviol inhibits the proliferation of human osteosarcoma U2OS cell line.CUL4A expression in pediatric osteosarcoma tissues and its effect on cell growth in osteosarcoma cells.Rapamycin: A promising agent to treat cancer pain?Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma

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P2860

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

http://www.wikidata.org/entity/Q36776382

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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name

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

@ast

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

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type

label

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

@ast

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

@en

prefLabel

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

@ast

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

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P1433

International Journal of Cancer

P1476

Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma.

@en

P2093

Charles Forscher

http://www.w3.org/2001/XMLSchema#string

Dhong Hyun Lee

http://www.w3.org/2001/XMLSchema#string

H Phillip Koeffler

http://www.w3.org/2001/XMLSchema#string

Henry Yang

http://www.w3.org/2001/XMLSchema#string

James E Bradner

http://www.w3.org/2001/XMLSchema#string

Jonathan W Said

http://www.w3.org/2001/XMLSchema#string

Jun Qi

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Ngan B Doan

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P2860

Selective inhibition of BET bromodomains

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Upstream and downstream of mTOR

The ENCODE (ENCyclopedia Of DNA Elements) Project

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

P304

2055-2064

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10.1002/IJC.29269

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9

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136

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2014-10-30T00:00:00Z

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25307878

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4824295

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