Sec61p contributes to signal sequence orientation according to the positive-inside rule.
about
Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranesThe concept of translocational regulationMembrane protein prediction methodsINS-gene mutations: from genetics and beta cell biology to clinical diseaseLateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranesLip1p: a novel subunit of acyl-CoA ceramide synthase.Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with AnemiaCharge asymmetry in the proteins of the outer membrane.Lipid-dependent generation of dual topology for a membrane protein.Tuning microbial hosts for membrane protein production.Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.Lipids and topological rules governing membrane protein assembly.The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration.Structural and functional profiling of the lateral gate of the Sec61 transloconMembrane protein insertion at the endoplasmic reticulum.Lipid-dependent membrane protein topogenesis.Lipids and topological rules of membrane protein assembly: balance between long and short range lipid-protein interactions.The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability.Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex.Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.Marginally hydrophobic transmembrane α-helices shaping membrane protein folding.SecY alterations that impair membrane protein folding and generate a membrane stress.Direct simulation of early-stage Sec-facilitated protein translocationVersatility of the endoplasmic reticulum protein folding factory.Regulation of multispanning membrane protein topology via post-translational annealing.Solving the membrane protein folding problem.Exploring the nature of the translocon-assisted protein insertion.Understanding integration of α-helical membrane proteins: the next stepsContribution of positively charged flanking residues to the insertion of transmembrane helices into the endoplasmic reticulum.To flip or not to flip: lipid-protein charge interactions are a determinant of final membrane protein topology.In vitro reconstitution of lipid-dependent dual topology and postassembly topological switching of a membrane protein.Lipid-protein interactions drive membrane protein topogenesis in accordance with the positive inside rule.An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.Membrane protein integration into the endoplasmic reticulum.Life at the border: adaptation of proteins to anisotropic membrane environment.The messy process of guiding proteins into membranes.Study of polytopic membrane protein topological organization as a function of membrane lipid composition.Protein translocation through the Sec61/SecY channel.Function of positive charges following signal-anchor sequences during translocation of the N-terminal domain.Effects of mixed proximal and distal topogenic signals on the topological sensitivity of a membrane protein to the lipid environment.
P2860
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P2860
Sec61p contributes to signal sequence orientation according to the positive-inside rule.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Sec61p contributes to signal sequence orientation according to the positive-inside rule.
@en
type
label
Sec61p contributes to signal sequence orientation according to the positive-inside rule.
@en
prefLabel
Sec61p contributes to signal sequence orientation according to the positive-inside rule.
@en
P2860
P356
P1476
Sec61p contributes to signal sequence orientation according to the positive-inside rule.
@en
P2093
Tina Junne
P2860
P304
P356
10.1091/MBC.E03-08-0599
P577
2003-12-10T00:00:00Z