Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene.
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Adenovirus E1A proteins interact with the cellular YY1 transcription factorAdenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcriptionp300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigenE1A promotes association between p300 and pRB in multimeric complexes required for normal biological activityRetinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.Modeling adenovirus latency in human lymphocyte cell lines.Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells.Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesisDistinct domains of adenovirus E1A interact with specific cellular factors to differentially modulate human immunodeficiency virus transcriptionRole of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejectionSuppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein.The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growthThe adenovirus E1A 12S product displays functional redundancy in activating the human proliferating cell nuclear antigen promoterThe adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.Induction of the cell cycle in baby rat kidney cells by adenovirus type 5 E1A in the absence of E1B and a possible influence of p53.The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cellsAnti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene.Repression of liver-specific hepatitis B virus enhancer 2 activity by adenovirus E1A proteins.Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene productsAdenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.Simian virus 40 large T-antigen function is required for induction of tetraploid DNA content during lytic infection.Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domainsE1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products.Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.Requirement of the adenovirus E1A transformation domain 1 for inhibition of PC12 cell neuronal differentiationInduction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1aInduction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activationAnalysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activityThe efficiency of adenovirus transformation of rodent cells is inversely related to the rate of viral E1A gene expression.Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.Expression and interactions of human adenovirus oncoproteins.Transforming growth factor beta 1 (TGF beta 1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRB binding activity.A protein kinase is present in a complex with adenovirus E1A proteinsComplementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.Maintenance of cellular proliferation by adenovirus early region 1A in fibroblasts conditionally immortalized by using simian virus 40 large T antigen requires conserved region 1.Interaction of a common factor with ATF, Sp1, or TATAA promoter elements is required for these sequences to mediate transactivation by the adenoviral oncogene E1a
P2860
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P2860
Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Interactions between cell grow ...... f the adenovirus E1A oncogene.
@en
type
label
Interactions between cell grow ...... f the adenovirus E1A oncogene.
@en
prefLabel
Interactions between cell grow ...... f the adenovirus E1A oncogene.
@en
P2860
P356
P1476
Interactions between cell grow ...... f the adenovirus E1A oncogene.
@en
P2093
P2860
P304
P356
10.1128/MCB.8.4.1756
P407
P577
1988-04-01T00:00:00Z