Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. - Wikidata - awgldk - TriplyDB

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

http://www.wikidata.org/entity/Q36793806

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Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy Rho GTPases in hematopoiesis and hemopathies Targeting the leukemia-stroma interaction in acute myeloid leukemia: rationale and latest evidence ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis A hostel for the hostile: the bone marrow niche in hematologic neoplasms Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia Hematopoietic stem cell niche maintenance during homeostasis and regeneration Animal models of leukemia: any closer to the real thing?In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML The rate of spontaneous mutations in human myeloid cells RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells.From pathway to population--a multiscale model of juxtacrine EGFR-MAPK signalling.Aging of the microenvironment influences clonality in hematopoiesis.CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling.Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling.DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3.Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction.Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis.Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy Cancer stem cells: a stride towards cancer cure?Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche.Nice neighborhood: emerging concepts of the stem cell niche.Contribution of an aged microenvironment to aging-associated myeloproliferative disease.Rac guanosine triphosphatases represent a potential target in AML Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage.Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice Induction of histiocytic sarcoma in mouse skeletal muscle.Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity.Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Contribution of bone microenvironment to leukemogenesis and leukemia progression.Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

http://www.wikidata.org/entity/Q36793806

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

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Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

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Catherine Fox

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James C Mulloy

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Jamie S Wilhelm

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Jorge F Dimartino

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Jose A Cancelas

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Juan C Cigudosa

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Junping Wei

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Mark Wunderlich

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Michael Jansen

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Sara Alvarez

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P2860

Creation of human tumour cells with defined genetic elements

Telomerase regulation and stem cell behaviour

Modeling the initiation and progression of human acute leukemia in mice

FLT3 as a therapeutic target in childhood acute leukemia

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Mll rearrangements in haematological malignancies: lessons from clinical and biological studies.

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

Stepwise reprogramming of B cells into macrophages.

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.

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