Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
about
Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitorsImmunological function in mice lacking the Rac-related GTPase RhoGRho GTPases in hematopoiesis and hemopathiesInterleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expressionRac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaBThe role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survivalDeficiency of small GTPase Rac2 affects T cell activationSWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migrationNf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signalingFer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cellsHyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functionsHyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitroGuanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis.Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturationA key role for ATF3 in regulating mast cell survival and mediator releaseMast cells and the neurofibroma microenvironmentNeurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascadesSHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axisThe PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells.On how Rac controls hematopoietic stem cell activity.Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation?Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cellsPak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression.The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cellsp21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
P2860
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P2860
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
description
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Mai 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/05/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/05/01)
@nl
наукова стаття, опублікована в травні 2000
@uk
مقالة علمية (نشرت في مايو 2000)
@ar
name
Rac2 stimulates Akt activation ...... function in primary mast cells
@ast
Rac2 stimulates Akt activation ...... function in primary mast cells
@en
Rac2 stimulates Akt activation ...... function in primary mast cells
@nl
type
label
Rac2 stimulates Akt activation ...... function in primary mast cells
@ast
Rac2 stimulates Akt activation ...... function in primary mast cells
@en
Rac2 stimulates Akt activation ...... function in primary mast cells
@nl
prefLabel
Rac2 stimulates Akt activation ...... function in primary mast cells
@ast
Rac2 stimulates Akt activation ...... function in primary mast cells
@en
Rac2 stimulates Akt activation ...... function in primary mast cells
@nl
P2093
P1433
P1476
Rac2 stimulates Akt activation ...... function in primary mast cells
@en
P2093
A. J. King
D. A. Williams
F. C. Yang
M. C. Dinauer
M. Marshall
P304
P356
10.1016/S1074-7613(00)80207-1
P407
P577
2000-05-01T00:00:00Z