Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. - Wikidata - awgldk - TriplyDB

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

http://www.wikidata.org/entity/Q36800896

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Interleukin-32 promotes osteoclast differentiation but not osteoclast activation Tartrate-resistant purple acid phosphatase is synthesized as a latent proenzyme and activated by cysteine proteinases Design of potent and selective human cathepsin K inhibitors that span the active site Importance of lysosomal cysteine proteases in lung disease From disease to treatment: from rare skeletal disorders to treatments for osteoporosis Optimizing dentin bond durability: control of collagen degradation by matrix metalloproteinases and cysteine cathepsins The emerging role of Interleukin 27 in inflammatory arthritis and bone destruction Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions Crystal structure of human cathepsin K complexed with a potent inhibitor Crystal structure of human osteoclast cathepsin K complex with E-64 Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification A putative role for cathepsin K in degradation of AA and AL amyloidosis Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones Cathepsin K inhibitors for osteoporosis and potential off-target effects Emerging techniques for the discovery and validation of therapeutic targets for skeletal diseases.Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library.Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice.Local application of osteoprotegerin-chitosan gel in critical-sized defects in a rabbit model Impact of dietary aromatic amino acids on osteoclastic activity Collagenase expression and activity in the stromal cells from giant cell tumour of bone.The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis.Characterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling.Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes.Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate.Novel therapeutic targets in osteoporosis.Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.Structural basis of collagen fiber degradation by cathepsin K.Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease.The clinical use of bone resorption markers in patients with malignant bone disease.Osteoclast differentiation and function in aquaglyceroporin AQP9-null mice.Cathepsin K is present in invasive oral tongue squamous cell carcinoma in vivo and in vitro ONO-5334, a cathepsin K inhibitor, improves bone strength by preferentially increasing cortical bone mass in ovariectomized rats.The effect of cathepsin K deficiency on airway development and TGF-β1 degradation.Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.

P2860

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P2860

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

http://www.wikidata.org/entity/Q36800896

description

1996 nî lūn-bûn

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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1996年论文

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1996年论文

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name

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

@ast

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

@en

type

label

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

@ast

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

@en

prefLabel

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

@ast

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

@en

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Journal of Biological Chemistry

P1476

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.

@en

P2093

Barthlow R

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Coleman L

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Connor JR

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Debouck C

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Dodds RA

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Drake FH

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Gowen M

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Hastings G

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James IE

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Lee-Rykaczewski E

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P2860

Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone

Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas

Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification

Sequence identification of 2,375 human brain genes

Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution

Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2

Inhibition of bone resorption in culture by inhibitors of thiol proteinases

Complementary DNA sequencing: expressed sequence tags and human genome project

Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets.

Inhibition of bone resorption by selective inactivators of cysteine proteinases.

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12511-12516

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21

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271

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