A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.
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Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control regionCloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expressionEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.A negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.cDNA cloning and function analysis of two novel erythroid differentiation related genes.Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic miceTwo types of precursor cells in a multipotential hematopoietic cell line.Age-dependent silencing of globin transgenes in the mouseLineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors.The developmental regulation of the human zeta-globin gene in transgenic mice employing beta-galactosidase as a reporter gene.Binary transgenic mouse model for studying the trans control of globin gene switching: evidence that GATA-1 is an in vivo repressor of human epsilon gene expressionHypersensitive sites in the 5' promoter region of nit-3, a highly regulated structural gene of Neurospora crassa.A globin enhancer acts by increasing the proportion of erythrocytes expressing a linked transgene.Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: suppression of a variegated cellular pattern of expression requires a full complement of distant ciTranscription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene.Enhancer-dependent transcription of the epsilon-globin promoter requires promoter-bound GATA-1 and enhancer-bound AP-1/NF-E2Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.Role of gene order in developmental control of human gamma- and beta-globin gene expression.Analysis of the human alpha-globin gene cluster in transgenic miceGerm-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic miceRegulated expression of the human beta globin gene in transgenic mice requires an upstream globin or nonglobin promoter.Enhancer activity of HS2 of the human beta-LCR is modulated by distance from the key nucleosomePosition effects in mice carrying a lacZ transgene in cis with the beta-globin LCR can be explained by a graded model.Established epigenetic modifications determine the expression of developmentally regulated globin genes in somatic cell hybridsThe roles of 5'-HS2, 5'-HS3, and the gamma-globin TATA, CACCC, and stage selector elements in suppression of beta-globin expression in early development.Bb1-3, a transgenic hybrid cell line with erythroid and megakaryocytic differentiation potential that expresses high levels of human gamma-globin and human beta-globin.HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter.Evolution of a fetal expression pattern via cis changes near the gamma globin gene.Conserved E boxes function as part of the enhancer in hypersensitive site 2 of the beta-globin locus control region. Role of basic helix-loop-helix proteins.Analysis of developmental switching in transgenic mice with 5' and 3' deletions in the human beta globin gene.
P2860
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P2860
A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
A single beta-globin locus con ...... obin genes in transgenic mice.
@ast
A single beta-globin locus con ...... obin genes in transgenic mice.
@en
type
label
A single beta-globin locus con ...... obin genes in transgenic mice.
@ast
A single beta-globin locus con ...... obin genes in transgenic mice.
@en
prefLabel
A single beta-globin locus con ...... obin genes in transgenic mice.
@ast
A single beta-globin locus con ...... obin genes in transgenic mice.
@en
P2093
P2860
P356
P1476
A single beta-globin locus con ...... obin genes in transgenic mice.
@en
P2093
P2860
P304
P356
10.1128/MCB.12.5.2057
P407
P577
1992-05-01T00:00:00Z