Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.
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Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control regionLocus control regionsChromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elementsQuantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCRGenomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacityA negative cis-element regulates the level of enhancement by hypersensitive site 2 of the beta-globin locus control region.Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control regionDevelopmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionSubstitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceSynergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancementThe beta-globin locus control region versus gene therapy vectors: a struggle for expression.Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region.Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.Beta-globin locus control region HS2 and HS3 interact structurally and functionallySequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locusFurther understanding of the beta-globin locus regulation at the molecular level: looping or linking models?Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1.The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cellsFunctional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesisDeletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenesSynergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.LCR 5' hypersensitive site specificity for globin gene activation within the active chromatin hub.Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells.Transcriptional mechanisms underlying hemoglobin synthesis.Antagonistic regulation of beta-globin gene expression by helix-loop-helix proteins USF and TFII-I.Identification of physical interactions between genomic regions by enChIP-Seq.Enhancer-dependent transcriptional oscillations in mouse erythroleukemia cells.Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.The higher structure of chromatin in the LCR of the beta-globin locus changes during development.Targeted deletion of the chicken beta-globin regulatory elements reveals a cooperative gene silencing activity.The roles of 5'-HS2, 5'-HS3, and the gamma-globin TATA, CACCC, and stage selector elements in suppression of beta-globin expression in early development.Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human beta-globin locus.Deletion of the human beta-globin LCR 5'HS4 or 5'HS1 differentially affects beta-like globin gene expression in beta-YAC transgenic mice.Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR.Hb S/β+-thalassemia due to Hb sickle and a novel deletion of DNase I hypersensitive sites HS3 and HS4 of the β locus control region.An Introduction to Erythropoiesis Approaches.
P2860
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P2860
Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Effect of deletion of 5'HS3 or ...... al chromosome transgenic mice.
@ast
Effect of deletion of 5'HS3 or ...... al chromosome transgenic mice.
@en
type
label
Effect of deletion of 5'HS3 or ...... al chromosome transgenic mice.
@ast
Effect of deletion of 5'HS3 or ...... al chromosome transgenic mice.
@en
prefLabel
Effect of deletion of 5'HS3 or ...... al chromosome transgenic mice.
@ast
Effect of deletion of 5'HS3 or ...... al chromosome transgenic mice.
@en
P2093
P2860
P356
P1476
Effect of deletion of 5'HS3 or ...... al chromosome transgenic mice.
@en
P2093
E J Norton
G Stamatoyannopoulos
K R Peterson
T G Kimbrough
P2860
P304
P356
10.1073/PNAS.93.13.6605
P407
P577
1996-06-01T00:00:00Z