Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
about
Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partnerIn vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reactionLocus control regionsCell signaling can direct either binary or graded transcriptional responsesDevelopmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletionThe locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Evolution of hemoglobin and its genesChromatin insulation by a transcriptional activator.Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosisUpstream distal regulatory elements contact the Lmo2 promoter in mouse erythroid cellsThe human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatinMultiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expressionA large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus.Structure and function of the murine beta-globin locus control region 5' HS-3.An upstream activator of transcription coordinately increases the level and epigenetic stability of gene expressionCharacterization of the chicken beta-globin insulatorLethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.A globin enhancer acts by increasing the proportion of erythrocytes expressing a linked transgene.Activity and expression of murine small Maf family protein MafK.A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.Functional and mechanistic diversity of distal transcription enhancers.An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells.Activation of the beta-globin locus control region precedes commitment to the erythroid lineage.New genes originated via multiple recombinational pathways in the beta-globin gene family of rodentsEvolution of duplicated beta-globin genes and the structural basis of hemoglobin isoform differentiation in MusDNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expressionProtein-DNA interactions in vivo of an erythroid-specific, human beta-globin locus enhancer.Chromatin structure and transcriptional control elements of the erythroid Krüppel-like factor (EKLF) gene.Sequences within and flanking hypersensitive sites 3 and 2 of the beta-globin locus control region required for synergistic versus additive interaction with the epsilon-globin gene promoter.Multiple regions of p45 NF-E2 are required for beta-globin gene expression in erythroid cells.Stochastic, stage-specific mechanisms account for the variegation of a human globin transgeneIntronic and flanking sequences are required to silence enhancement of an embryonic beta-type globin gene.Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.Comparative analysis of the locus control region of the rabbit beta-like gene cluster: HS3 increases transient expression of an embryonic epsilon-globin gene.Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci.The mouse beta-globin locus control region: hypersensitive sites 3 and 4.Characterization of the major regulatory element upstream of the human alpha-globin gene cluster.NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human beta-globin locus control region.Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the beta-globin locus control region. Domain opening and synergism between HS2 and HS3.Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun.
P2860
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P2860
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
description
1990 nî lūn-bûn
@nan
1990 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Conservation of the primary st ...... obin locus-activating regions.
@ast
Conservation of the primary st ...... obin locus-activating regions.
@en
type
label
Conservation of the primary st ...... obin locus-activating regions.
@ast
Conservation of the primary st ...... obin locus-activating regions.
@en
prefLabel
Conservation of the primary st ...... obin locus-activating regions.
@ast
Conservation of the primary st ...... obin locus-activating regions.
@en
P2860
P356
P1476
Conservation of the primary st ...... obin locus-activating regions.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.19.7693
P407
P577
1990-10-01T00:00:00Z