Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.
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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionOverexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expressionInteraction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinaseEvidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion.Identification of a PTEN-regulated STAT3 brain tumor suppressor pathwayRegulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayActivation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destructionLoss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressorNovel allosteric sites on Ras for lead generationA kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastomaEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function researchInhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flowPleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growthA secreted PTEN phosphatase that enters cells to alter signaling and survivalDisruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuseInhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cellsNovel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancersMutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsPTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayNew insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayStructural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancerPTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity.Neuronal transcription factors induce conversion of human glioma cells to neurons and inhibit tumorigenesis.Manipulating insulin signaling to enhance mosquito reproduction.Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsThe PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.Germline PTEN mutations in Cowden syndrome-like families.Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.PTEN gene and integrin signaling in cancer.FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytesModulation of cellular apoptotic potential: contributions to oncogenesis.Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling.PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase.
P2860
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P2860
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Growth suppression of glioma c ...... phosphatase catalytic domain.
@ast
Growth suppression of glioma c ...... phosphatase catalytic domain.
@en
type
label
Growth suppression of glioma c ...... phosphatase catalytic domain.
@ast
Growth suppression of glioma c ...... phosphatase catalytic domain.
@en
prefLabel
Growth suppression of glioma c ...... phosphatase catalytic domain.
@ast
Growth suppression of glioma c ...... phosphatase catalytic domain.
@en
P2093
P2860
P356
P1476
Growth suppression of glioma c ...... phosphatase catalytic domain.
@en
P2093
P2860
P304
12479-12484
P356
10.1073/PNAS.94.23.12479
P407
P577
1997-11-01T00:00:00Z