PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity. - Wikidata - awgldk - TriplyDB

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity.

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity.

http://www.wikidata.org/entity/Q30434033

about

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development A quantitative proteomic analysis uncovers the relevance of CUL3 in bladder cancer aggressiveness.Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma.Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination.Biology of urothelial tumorigenesis: insights from genetically engineered mice.Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer Suppression of human lung cancer cell proliferation and metastasis in vitro by the transducer of ErbB-2.1 (TOB1).Periostin suppresses in vivo invasiveness via PDK1/Akt/mTOR signaling pathway in a mouse orthotopic model of bladder cancer A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/β-catenin/CBP pathway.Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?PTEN in brain tumors.PTEN: a default gate-keeping tumor suppressor with a versatile tail.PTEN: a new guardian of the genome.Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression.Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway.The PI3K signaling pathway mediates the biological effects of leptin.Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3β mediated regulation of p21 in human urothelial carcinoma cells Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity.Identification of nucleolus-localized PTEN and its function in regulating ribosome biogenesis.PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells Development of a quantitative method to analyse tumour cell invasion in organotypic culture.Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor.Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.Nongenomic Mechanisms of PTEN Regulation.Inhibition of miRNA-21 attenuates the proliferation and metastasis of human osteosarcoma by upregulating PTEN.Hematopoietic Stem Cell Activity Is Regulated by Pten Phosphorylation Through a Niche-Dependent Mechanism.

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P2860

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity.

http://www.wikidata.org/entity/Q30434033

description

2004 nî lūn-bûn

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2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

PTEN can inhibit in vitro orga ...... ts lipid phosphatase activity.

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PTEN can inhibit in vitro orga ...... ts lipid phosphatase activity.

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type

label

PTEN can inhibit in vitro orga ...... ts lipid phosphatase activity.

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PTEN can inhibit in vitro orga ...... ts lipid phosphatase activity.

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PTEN can inhibit in vitro orga ...... ts lipid phosphatase activity.

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PTEN can inhibit in vitro orga ...... ts lipid phosphatase activity.

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PTEN can inhibit in vitro orga ...... ts lipid phosphatase activity.

@en

P2093

Dan Theodorescu

http://www.w3.org/2001/XMLSchema#string

Henry F Frierson

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John J Gildea

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Kathryn M Gulding

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Mikael Herlevsen

http://www.w3.org/2001/XMLSchema#string

P2860

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

PTEN: life as a tumor suppressor

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Genetic and phenotypic changes associated with the acquisition of tumorigenicity in human bladder cancer.

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

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40

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23

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Michael A Harding

Christopher Moskaluk

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2004-09-01T00:00:00Z

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8435476

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1052702941

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15273733

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