Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA.
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The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domainA herpesvirus genetic element which affects translation in the absence of the viral GADD34 functionAssociation of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptidesBinding of herpes simplex virus-1 US11 to specific RNA sequencesA herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function.The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein.Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain.In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation.The herpes simplex virus type 1 US11 protein binds the coterminal UL12, UL13, and UL14 RNAs and regulates UL13 expression in vivo.Nucleolin interacts with US11 protein of herpes simplex virus 1 and is involved in its traffickingBiophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene.Structure and function in the herpes simplex virus 1 RNA-binding protein U(s)11: mapping of the domain required for ribosomal and nucleolar association and RNA binding in vitroAssemblons: nuclear structures defined by aggregation of immature capsids and some tegument proteins of herpes simplex virus 1The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene.Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells.A herpes simplex virus 1 US11-expressing cell line is resistant to herpes simplex virus infection at a step in viral entry mediated by glycoprotein DThe herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunitsThe gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein alpha 22.Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells.Evolution and diversity in human herpes simplex virus genomes.Herpes simplex virus type 1 U(L)34 gene product is required for viral envelopment.Mutations in herpes simplex virus glycoprotein D distinguish entry of free virus from cell-cell spread.Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle.
P2860
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P2860
Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Herpes simplex virus 1 RNA-bin ...... ion of a truncated viral mRNA.
@en
type
label
Herpes simplex virus 1 RNA-bin ...... ion of a truncated viral mRNA.
@en
prefLabel
Herpes simplex virus 1 RNA-bin ...... ion of a truncated viral mRNA.
@en
P2860
P1433
P1476
Herpes simplex virus 1 RNA-bin ...... ion of a truncated viral mRNA.
@en
P2093
R J Roller
P2860
P304
P407
P577
1991-11-01T00:00:00Z