Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling.
about
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15Insights into cytokine-receptor interactions from cytokine engineeringCrystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentationIdentification of an interleukin-15alpha receptor-binding site on human interleukin-15Selective enhancement of thrombopoietic activity of PEGylated interleukin 6 by a simple procedure using a reversible amino-protective reagent.Novel human interleukin-15 agonistsExpression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cisInhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.In vivo anti-tumor activity of polypeptide HM-3 modified by different polyethylene glycols (PEG).Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates.Interleukin-6 trans-signalling in chronic inflammation and cancer.Reprogramming of B cells into regulatory cells with engineered fusokinesTargeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivityDistinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.Clinical manufacturing of recombinant human interleukin 15. I. Production cell line development and protein expression in E. coli with stop codon optimization.Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model.PEGylation of osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF) results in decreased uptake into rats and human liver.Cutting Edge: Differential Fine-Tuning of IL-2- and IL-15-Dependent Functions by Targeting Their Common IL-2/15Rβ/γc Receptor.
P2860
Q24301975-59BE21A5-F6A4-4849-BD13-188B475F1709Q26852703-F4DD25C2-036C-433B-8EB5-B1953C7EC38FQ27648832-9D4626A3-651C-407E-838C-23B42A5F0824Q28252347-CD17DCE7-B279-4A1C-8EC1-3ABF69823EA0Q31893425-5F441BC4-8727-4189-9B76-4AF7C25D8669Q33623266-513492A3-3542-4E9B-A88B-645C0F298C52Q34415755-A3B151E3-784A-48CB-81EF-8604C57817C6Q34766657-F6C8E070-2B59-422C-A474-646B4A03AD62Q35079289-46B1F74E-392D-4ADE-9A5C-C17F5140D84CQ36145575-A76E4CCB-8066-48A1-BE7A-358CFF45A337Q36460931-03B27DF5-4DED-4B31-B7DE-6CFE7318D2EBQ37066073-B0F1C9F7-0210-4F5C-80EB-FBCCEB5622A8Q37250358-2C78CA25-3CDE-4970-B205-0AB0C5201DF5Q37682391-283E8761-DE62-4476-AA34-8A06380E95B1Q39429309-245F043F-7215-45A1-AB82-50DD0A33255DQ39691985-E3D7EBBC-6AA7-45E9-9B0B-53E223500834Q40156550-850F701C-4509-4B4C-B69A-E121A8E676A1Q42956109-5A2DDA02-0FCD-4EB2-A1F4-4162D0AB77B0Q48142431-C21E2DDB-9715-4B61-810B-03DC08C66322
P2860
Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Structure-function studies of ...... gation, and homology modeling.
@en
type
label
Structure-function studies of ...... gation, and homology modeling.
@en
prefLabel
Structure-function studies of ...... gation, and homology modeling.
@en
P2093
P2860
P356
P1476
Structure-function studies of ...... gation, and homology modeling.
@en
P2093
Bonnert TP
Eisenman J
Gombotz WR
Grabstein KH
Srinivasan S
P2860
P304
P356
10.1074/JBC.272.4.2312
P407
P577
1997-01-01T00:00:00Z