Role for neuronal insulin resistance in neurodegenerative diseases - Wikidata - awgldk - TriplyDB

Role for neuronal insulin resistance in neurodegenerative diseases

Role for neuronal insulin resistance in neurodegenerative diseases

http://www.wikidata.org/entity/Q36853917

about

Evolutionary origins of insulin resistance: a behavioral switch hypothesis Insulin in central nervous system: more than just a peripheral hormone Brain fuel metabolism, aging, and Alzheimer's disease Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics The Rationale for Insulin Therapy in Alzheimer's Disease Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction Alzheimer's Disease: Mechanism and Approach to Cell Therapy Metabolic Alterations Associated to Brain Dysfunction in Diabetes Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art Alzheimer's disease and insulin resistance: translating basic science into clinical applications Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease Roles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factors Aberrant insulin signaling in Alzheimer's disease: current knowledge The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life The dendritic hypothesis for Alzheimer's disease pathophysiology.Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease Altered regulation of Akt signaling with murine cerebral malaria, effects on long-term neuro-cognitive function, restoration with lithium treatment G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice The role of ribosylated-BSA in regulating PC12 cell viability.Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer's disease Insulin, cognition, and dementia Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice.Diabetes mellitus: channeling care through cellular discovery Insulin action in brain regulates systemic metabolism and brain function.Reduced lean mass in early Alzheimer disease and its association with brain atrophy.Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice.Cardiovascular risk factors and frontotemporal dementia: a case-control study Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology.CSF and Brain Indices of Insulin Resistance, Oxidative Stress and Neuro-Inflammation in Early versus Late Alzheimer's Disease Increased Alzheimer's disease neuropathology is associated with type 2 diabetes and ApoE ε.4 carrier status.

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Role for neuronal insulin resistance in neurodegenerative diseases

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2004年论文

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2004年论文

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Role for neuronal insulin resistance in neurodegenerative diseases

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Role for neuronal insulin resistance in neurodegenerative diseases

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Role for neuronal insulin resistance in neurodegenerative diseases

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Role for neuronal insulin resistance in neurodegenerative diseases

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P2093

Andreas H Jacobs

http://www.w3.org/2001/XMLSchema#string

David Surjo

http://www.w3.org/2001/XMLSchema#string

Dinesh Gautam

http://www.w3.org/2001/XMLSchema#string

Dominic Schubert

http://www.w3.org/2001/XMLSchema#string

Eckehardt Küstermann

http://www.w3.org/2001/XMLSchema#string

Jens Alber

http://www.w3.org/2001/XMLSchema#string

Kojihiko Ueki

http://www.w3.org/2001/XMLSchema#string

Markus Schubert

http://www.w3.org/2001/XMLSchema#string

Norbert Galldiks

http://www.w3.org/2001/XMLSchema#string

Saskia Arndt

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P2860

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Central nervous system control of food intake

Regulation of neuronal survival by the serine-threonine protein kinase Akt

Single and multiple transgenic mice as models for Alzheimer's disease.

Sniffing neuropeptides: a transnasal approach to the human brain.

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

Does insulin dysfunction play a role in Alzheimer's disease?

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

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3100-3105

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101

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Jens C Brüning

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5248529

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14981233

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neurodegeneration

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365750

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