Folding versus aggregation: polypeptide conformations on competing pathways
about
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisMolecular mechanism and structure of Trigger Factor bound to the translating ribosomeConformational Conversion during Amyloid Formation at Atomic ResolutionTrimming Down a Protein Structure to Its Bare Foldons: SPATIAL ORGANIZATION OF THE COOPERATIVE UNITMechanism of Protein Kinetic Stabilization by Engineered Disulfide CrosslinksEnergetically significant networks of coupled interactions within an unfolded proteinUnraveling Comparative Anti-Amyloidogenic Behavior of Pyrazinamide and D-Cycloserine: A Mechanistic Biophysical InsightOrdered self-assembly mechanism of a spherical oncoprotein oligomer triggered by zinc removal and stabilized by an intrinsically disordered domainMapping the structure of amyloid nucleation precursors by protein engineering kinetic analysis.Effects of surface interactions on peptide aggregate morphology.Cutting off functional loops from homodimeric enzyme superoxide dismutase 1 (SOD1) leaves monomeric β-barrels.Effect of beta-sheet propensity on peptide aggregation.Zinc binding modulates the entire folding free energy surface of human Cu,Zn superoxide dismutase.The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicityInvestigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurementsAGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures.Identification of fibrillogenic regions in human triosephosphate isomerase.Comparing the folding and misfolding energy landscapes of phosphoglycerate kinase.Structural characterization of MG and pre-MG states of proteins by MD simulations, NMR, and other techniques.A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates.Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.Heat-induced irreversible denaturation of the camelid single domain VHH antibody is governed by chemical modifications.Inducible polymerization and two-dimensional assembly of the repeats-in-toxin (RTX) domain from the Pseudomonas aeruginosa alkaline protease.Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.Illuminating the off-pathway nature of the molten globule folding intermediate of an α-β parallel protein.Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosisEvolutionary trend toward kinetic stability in the folding trajectory of RNases H.Defining the limits: Protein aggregation and toxicity in vivoLysophospholipid-containing membranes modulate the fibril formation of the repeat domain of a human functional amyloid, pmel17.Hydrophobic collapse of trigger factor monomer in solutionSpatial quality control bypasses cell-based limitations on proteostasis to promote prion curing.Chaperones in control of protein disaggregation.Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue levelProtein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape.Amyloid fibril formation by the glaucoma-associated olfactomedin domain of myocilin.Folding without charges.Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicitySpecific soluble oligomers of amyloid-β peptide undergo replication and form non-fibrillar aggregates in interfacial environmentsA New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation.A solenoid design for assessing determinants of parallel β-sheet registration.
P2860
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P2860
Folding versus aggregation: polypeptide conformations on competing pathways
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Folding versus aggregation: polypeptide conformations on competing pathways
@en
Folding versus aggregation: polypeptide conformations on competing pathways
@en-gb
type
label
Folding versus aggregation: polypeptide conformations on competing pathways
@en
Folding versus aggregation: polypeptide conformations on competing pathways
@en-gb
prefLabel
Folding versus aggregation: polypeptide conformations on competing pathways
@en
Folding versus aggregation: polypeptide conformations on competing pathways
@en-gb
P2860
P1476
Folding versus aggregation: polypeptide conformations on competing pathways
@en
P2860
P304
P356
10.1016/J.ABB.2007.05.015
P407
P577
2007-06-08T00:00:00Z