Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas - Wikidata - awgldk - TriplyDB

Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas

Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas

http://www.wikidata.org/entity/Q36865995

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Metabolic consequences of oncogenic IDH mutations Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.Is there pseudoprogression in secondary glioblastomas?Genomic dynamics associated with malignant transformation in IDH1 mutated gliomas.What do we know about IDH1/2 mutations so far, and how do we use it?Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas.D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma Development of a LC-MS/MS Method for the Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates in a Range of Biological Matrices.

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P2860

Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas

http://www.wikidata.org/entity/Q36865995

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年论文

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name

Accumulation of 2-hydroxygluta ...... IDH-mutated low-grade gliomas

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Accumulation of 2-hydroxygluta ...... IDH-mutated low-grade gliomas

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Accumulation of 2-hydroxygluta ...... IDH-mutated low-grade gliomas

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Accumulation of 2-hydroxygluta ...... IDH-mutated low-grade gliomas

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Dietmar Krex

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Gabriele Schackert

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Graeme Eisenhofer

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Kathrin Geiger

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Mirko Peitzsch

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P2860

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

An integrated genomic analysis of human glioblastoma multiforme

IDH1 and IDH2 mutations in gliomas

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

Surgical resection for patients with benign primary brain tumors and low grade gliomas.

Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review.

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group.

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

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10.1093/NEUONC/NOT006

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6

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15

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Tareq A Juratli

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