The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection
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Herpes simplex virus latency-associated transcript is a stable intronBovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisIdentification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT): translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT.Isolation and characterization of a functional cDNA encoding ICP0 from herpes simplex virus type 1EBV gene expression in an NPC-related tumour.Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.Genetic studies exposing the splicing events involved in herpes simplex virus type 1 latency-associated transcript production during lytic and latent infection.Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycleThe locus encompassing the latency-associated transcript of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal Ganglia of acutely infected mice.Alternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading framesSmall non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.Analysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same regionRegion of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue cultureHerpes simplex virus type 1 latency-associated transcript expression protects trigeminal ganglion neurons from apoptosis.Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency.Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.The herpes simplex virus type 1 locus that encodes the latency-associated transcript enhances the frequency of encephalitis in male BALB/c miceStructural and kinetic analyses of herpes simplex virus type 1 latency-associated transcripts in human trigeminal ganglia and in cell cultureCellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice.Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.The 2-kilobase intron of the herpes simplex virus type 1 latency-associated transcript has a half-life of approximately 24 hours in SY5Y and COS-1 cells.The stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cellsHerpes simplex virus type 1 and bovine herpesvirus 1 latency.Experimental investigation of herpes simplex virus latencyUpdate on emerging antivirals for the management of herpes simplex virus infections: a patenting perspective.The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation.The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript.Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latencyA 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinearThe abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia.The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosineThe herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latencySelection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcriptA LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1.Herpes simplex virus genome replication and transcription during induced reactivation in the rabbit eye.Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear EnvironmentExpression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs
P2860
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P2860
The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
The herpes simplex virus laten ...... the latent phase of infection
@en
type
label
The herpes simplex virus laten ...... the latent phase of infection
@en
prefLabel
The herpes simplex virus laten ...... the latent phase of infection
@en
P2093
P2860
P1433
P1476
The herpes simplex virus laten ...... the latent phase of infection
@en
P2093
E K Wagner
G Devi-Rao
J G Stevens
K P Anderson
W M Flanagan
P2860
P304
P407
P577
1988-12-01T00:00:00Z