A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1.
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Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latencyHerpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection.MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic ConsiderationsBovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisThe molecular basis of herpes simplex virus latencyOcular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?Role of chromatin during herpesvirus infections.Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivationEpigenetic analysis of KSHV latent and lytic genomes.Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycleEpigenetic regulation of latent HSV-1 gene expression.The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal gangliaAlternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading framesImmunohistochemical analysis of primary sensory neurons latently infected with herpes simplex virus type 1.Long-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression.The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.Evidence for a bidirectional element located downstream from the herpes simplex virus type 1 latency-associated promoter that increases its activity during latencyOptimized viral dose and transient immunosuppression enable herpes simplex virus ICP0-null mutants To establish wild-type levels of latency in vivo.Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latencySmall non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same regionICP0, ICP4, or VP16 expressed from adenovirus vectors induces reactivation of latent herpes simplex virus type 1 in primary cultures of latently infected trigeminal ganglion cells.Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue cultureHerpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency.Lytic gene expression is frequent in HSV-1 latent infection and correlates with the engagement of a cell-intrinsic transcriptional responseA herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse.A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency.Snapshots: chromatin control of viral infection.A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levelsHistone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cellsNeither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virusRegions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAsThe stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cellsTranscription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters.
P2860
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P2860
A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A LAT-associated function redu ...... h herpes simplex virus type 1.
@ast
A LAT-associated function redu ...... h herpes simplex virus type 1.
@en
type
label
A LAT-associated function redu ...... h herpes simplex virus type 1.
@ast
A LAT-associated function redu ...... h herpes simplex virus type 1.
@en
prefLabel
A LAT-associated function redu ...... h herpes simplex virus type 1.
@ast
A LAT-associated function redu ...... h herpes simplex virus type 1.
@en
P2093
P2860
P1433
P1476
A LAT-associated function redu ...... th herpes simplex virus type 1
@en
P2093
D A Garber
P A Schaffer
P2860
P304
P407
P577
1997-08-01T00:00:00Z