Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
about
Mitophagy plays a central role in mitochondrial ageingMitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?Mitochondrial dynamism and heart disease: changing shape and shaping changeProteostasis and longevity: when does aging really begin?New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heartMitochondrial proteostasis in the control of aging and longevityComplex-I-ty in agingPathologic and therapeutic implications for the cell biology of parkinPhosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tetheringPINK1-mediated phosphorylation of Parkin boosts Parkin activity in DrosophilaFine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogasterDysregulation of autophagy and mitochondrial function in Parkinson's diseaseQuality control systems in cardiac agingMitophagy and heart failureMitochondrial quality control in the myocardium: cooperation between protein degradation and mitophagyMorphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathwayThe diabetes susceptibility gene Clec16a regulates mitophagyThe accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.AMPK modulates tissue and organismal aging in a non-cell-autonomous mannerA mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila.Higher expression of somatic repair genes in long-lived ant queens than workersLoss of Nfkb1 leads to early onset agingThe mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble.Mitochondrial maintenance failure in aging and role of sexual dimorphism.Mask loss-of-function rescues mitochondrial impairment and muscle degeneration of Drosophila pink1 and parkin mutantsImpaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary diseasePARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.Longevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis.Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.Mitochondrial morphology is altered in atrophied skeletal muscle of aged miceThe roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseaseThe Mitochondrial Basis of Aging.Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal LifespanPathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disordersIncreased levels of hyper-stable protein aggregates in plasma of older adults.Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.Mitochondrial quality control in insulin resistance and diabetes.In serum veritas-in serum sanitas? Cell non-autonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathwayHappily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence.
P2860
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P2860
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Parkin overexpression during a ...... dynamics, and extends lifespan
@en
type
label
Parkin overexpression during a ...... dynamics, and extends lifespan
@en
prefLabel
Parkin overexpression during a ...... dynamics, and extends lifespan
@en
P2860
P356
P1476
Parkin overexpression during a ...... dynamics, and extends lifespan
@en
P2093
David W Walker
P2860
P304
P356
10.1073/PNAS.1216197110
P407
P50
P577
2013-05-06T00:00:00Z