Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines
about
Protein binding has a large effect on radical mediated DNA damage.Reactivity of Nucleic Acid Radicals.Synthesis of cross-linked DNA containing oxidized abasic site analogues.Reactive oxygen species (ROS) inducible DNA cross-linking agents and their effect on cancer cells and normal lymphocytes.Interstrand cross-link and bioconjugate formation in RNA from a modified nucleotide.Fluorescent xDNA nucleotides as efficient substrates for a template-independent polymerase.Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs.Direct formation of the C5'-radical in the sugar-phosphate backbone of DNA by high-energy radiation.DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases.Photouncaged Sequence-specific Interstrand DNA Cross-Linking with Photolabile 4-oxo-enal-modified Oligonucleotides.Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts.ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block.Multinuclear NMR and kinetic analysis of DNA interstrand cross-link formation.Scope and mechanism of interstrand cross-link formation by the C4'-oxidized abasic site.The leaving group strongly affects H₂O₂-induced DNA cross-linking by arylboronates.Induced cross-linking reactions to target genes using modified oligonucleotides.Reactions templated by nucleic acids: more ways to translate oligonucleotide-based instructions into emerging function.Triplex crosslinking through furan oxidation requires perturbation of the structured triple-helix.Photo-triggered fluorescent theranostic prodrugs as DNA alkylating agents for mechlorethamine release and spatiotemporal monitoring.Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug.5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells.Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA.4-vinyl-substituted pyrimidine nucleosides exhibit the efficient and selective formation of interstrand cross-links with RNA and duplex DNAAromatic nitrogen mustard-based prodrugs: activity, selectivity, and the mechanism of DNA cross-linking.Independent Generation and Reactivity of Thymidine Radical Cations.Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides.Furan-oxidation-triggered inducible DNA cross-linking: acyclic versus cyclic furan-containing building blocks--on the benefit of restoring the cyclic sugar backbone.Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate.
P2860
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P2860
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines
@en
type
label
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines
@en
prefLabel
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines
@en
P2093
P2860
P356
P1476
Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines
@en
P2093
In Seok Hong
Marc M Greenberg
Michael M Seidman
Xiaohua Peng
P2860
P304
10299-10306
P356
10.1021/JA802177U
P407
P577
2008-07-12T00:00:00Z