Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling. - Wikidata - awgldk - TriplyDB

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling.

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling.

http://www.wikidata.org/entity/Q36923647

about

Ins and outs of GPCR signaling in primary cilia Polycystic liver diseases: advanced insights into the molecular mechanisms Bile acid signaling and biliary functions Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia.Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma.TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation Biological properties of extracellular vesicles and their physiological functions.A TRPM4-dependent current in murine renal primary cilia.Isolation, identification, and characterization of novel nanovesicles TGR5, Not Only a Metabolic Regulator.The bile acid TGR5 membrane receptor: from basic research to clinical application.TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?Therapeutic Targets in Polycystic Liver Disease.Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease.The primary cilium as a cellular receiver: organizing ciliary GPCR signaling TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.Saturated free fatty acids induce cholangiocyte lipoapoptosis.The cholangiocyte primary cilium in health and disease.Mechanisms of cholangiocyte responses to injury.Pathobiology of biliary epithelia.TGR5 in the Cholangiociliopathies.G-Protein-Coupled Receptor Signaling in Cilia.TGR5 expression in normal kidney and renal neoplasms.Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma

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P2860

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling.

http://www.wikidata.org/entity/Q36923647

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

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2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Ciliary subcellular localizati ...... sponse to bile acid signaling.

@en

type

label

Ciliary subcellular localizati ...... sponse to bile acid signaling.

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prefLabel

Ciliary subcellular localizati ...... sponse to bile acid signaling.

@en

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AJPGI.00383.2012

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American Journal of Physiology - Gastrointestinal and Liver Physiology

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Ciliary subcellular localizati ...... sponse to bile acid signaling.

@en

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Anatoliy I Masyuk

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Bing Q Huang

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Brynn N Radtke

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Gabriella B Gajdos

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Nicholas F LaRusso

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Patrick L Splinter

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Sergio A Gradilone

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Tatyana V Masyuk

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of membrane-type receptor for bile acids (M-BAR)

A G protein-coupled receptor responsive to bile acids

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells.

Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.

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G1013-24

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scholarly article

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10.1152/AJPGI.00383.2012

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11

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304

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2013-04-11T00:00:00Z

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23578785

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