Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. - Wikidata - awgldk - TriplyDB

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

http://www.wikidata.org/entity/Q36945144

about

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation Simultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathways Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination ATAD5 deficiency decreases B cell division and Igh recombination The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Histone H2A and H2B are monoubiquitinated at AID-targeted loci.Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.AID and somatic hypermutation.Msh6 protects mature B cells from lymphoma by preserving genomic stability.An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain.Mismatch-mediated error prone repair at the immunoglobulin genes.DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase Does DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils.Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination.The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.Identification of host cellular proteins that interact with the M protein of a highly pathogenic porcine reproductive and respiratory syndrome virus vaccine strain.Roles of sequential ubiquitination of PCNA in DNA-damage tolerance.Translesion DNA synthesis and mutagenesis in eukaryotes AID and APOBEC deaminases: balancing DNA damage in epigenetics and immunity.Meiotic Recombination: The Essence of Heredity.The gene expression profiling of hepatocellular carcinoma by a network analysis approach shows a dominance of intrinsically disordered proteins (IDPs) between hub nodes.PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions.Target validation and structure-activity analysis of a series of novel PCNA inhibitors

P2860

Q24299397-05226F29-28F0-47BE-A53D-3F489A011FA3 Q24307502-D227CDB4-BF46-4FE7-94D0-5770E3AECE0C Q24595974-3D84E2CF-D5FE-451B-91BD-94957D08AFD7 Q27324793-9AAFA0C1-C926-4A26-B59A-25D90E174B54 Q27437920-E363F739-0701-44CF-89CE-DDF9EB605ADE Q28078919-F29BD806-4D10-4B32-B8D9-46DFE9DC8558 Q28241953-B208C973-F06C-4991-AA2C-4BC4D1ADCEE9 Q28536559-B93E91AB-B688-42AD-937A-38C1DDBD8D06 Q28565443-5FF622EF-A8F3-4200-A69D-BC0FD1C4E3F1 Q28592784-C98670A7-A81E-42A6-B8CF-8A90FFA82865 Q28592936-EB69085A-A4C9-48EE-8A7A-4A04309F1CBE Q30994273-73AE064C-12C8-47E8-B6E7-AF3AAC4339A1 Q33557562-6E3EC882-40F9-4B8B-907B-1E8D7E06E1B9 Q33641304-361A113F-794D-472C-A71E-B147A3D6D69F Q33815487-DAAB12E9-3422-420E-AB2A-6E2EF4311D4F Q34068165-756774CE-A18B-409D-AC7B-ABD9DCCA09E7 Q34118000-DF3DCD4F-050F-4B3B-AA9A-4DC86780762F Q34254602-8ECC3024-98BE-41F8-95FA-95ED44D0E210 Q34588854-19197697-9EA4-485D-86F4-8BF983B6D4D5 Q34735827-F8A3DEDF-935D-4578-8FD4-9CFF717A21D4 Q34796010-13C0B33F-D263-4930-BB0F-AB7854498EF7 Q35605313-9C54E837-AA51-42A8-9FF9-2666C84DC898 Q36021801-90307C7D-49CD-46EC-9A12-D350CD5629C2 Q36054241-ED3B0F18-7109-4B95-97E7-C340EE17C727 Q36173864-697BC5C3-43CE-49C6-89D5-E6B866BC6EDE Q36173942-739342A0-B765-491E-B764-A8A2D5BF21FF Q36540495-4A7861C6-BBB3-4E2B-BEE8-3BD5B584BCE2 Q36684782-D8217649-7F29-4148-8EC8-7C406CB049A4 Q37047453-4AC3741E-4A49-4E13-852D-FD40A9F247C2 Q37124102-6520253B-97A7-4B93-AB3E-F00100449199 Q37334051-4FDC4FFA-8894-41E8-A459-A4022729F9D9 Q37528812-6029719D-D043-4906-8E9A-6F1699C29FEC Q37658527-BAAD147D-F64F-4D5C-859C-09A7D9932D8C Q37871124-9C46FEFE-5808-4C31-BA87-D82F7EF7B50F Q38086224-ED597A48-2BF2-4FED-B2A3-284161355374 Q38261749-22A339C1-9AD1-4B9A-9145-4F6B19B128FF Q38618828-FB8AD89D-EEF8-476E-8995-A3A081267614 Q38844234-1EADBA6A-ACB9-42D9-A7A5-47A46CD59D25 Q39028575-75E403A3-28E1-42A5-B806-6672DB6054BC Q39034053-D7231385-60BE-4C2A-85FF-ED2C807135FF

P2860

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

http://www.wikidata.org/entity/Q36945144

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.

@en

type

label

Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.

@en

prefLabel

Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.

@en

P1433

Q36945144-A9059D66-7CFB-4417-9D65-01B90383D12B

P1476

Q36945144-6B95E1C0-90E2-4E5F-ADFE-7EEB906E252E

P2093

Q36945144-256D5D3A-19A1-4D87-AC58-8BABD1F39DDD

Q36945144-3EAC574A-9707-4B59-95E7-B5A1F4B6C50D

Q36945144-5B81C5C7-A94E-494C-8A05-3297C8E9B424

Q36945144-68E147E1-F94E-4B9A-8A54-5776807EE087

Q36945144-9333680D-2114-43D4-A11F-8FA0AF15B9EB

Q36945144-9A8BD85B-24A8-44E4-BB17-0C139DC0CFEB

Q36945144-C1226AB4-EBAA-418F-A639-80EA22A6BF1C

Q36945144-C134934C-0683-41A2-A68E-411205D088E6

Q36945144-CBECF296-05BF-43C9-8E09-243BF60EFEAC

Q36945144-D4B4353B-54B7-4BBC-A183-6414BAF98EA3

P2860

Q36945144-01E62E9B-F65E-4DBA-B0B3-C9293260E3E9

Q36945144-02355429-6D8B-44DF-805F-F334D1C36CD9

Q36945144-1911619E-3FA5-40D2-B442-84DCC3B911EF

Q36945144-195C0BAE-F4F9-4AA9-B3CC-F9249BBC3940

Q36945144-25AB1848-C942-42E0-B7ED-1F08AE188B04

Q36945144-25FE58CF-7559-4AB9-9EBE-C2ADF891D2E9

Q36945144-28A7108A-F64E-460B-AA3D-621BB1FA8D09

Q36945144-347D8269-FA8A-4797-A703-EA92F7390823

Q36945144-39860E74-6A9D-4345-A004-B96CE13422D0

Q36945144-3AEB685D-5AEF-452D-9651-DBC01B6AFE24

P304

Q36945144-491FD53C-6DF0-4E5D-A9C5-6BB58673F967

P31

Q36945144-10595D99-E192-46FC-A495-61CF27FB5459

P356

Q36945144-884C5E87-83E6-4EB8-8817-B263418ABA1F

P407

Q36945144-C77C080F-46BF-436C-82AC-20661C6A1C77

P433

Q36945144-8FE2E032-07D7-4D25-A6E1-82A12C56A07E

P478

Q36945144-FCB5E0BD-6592-4030-9787-6C92AF270FB4

P577

Q36945144-EE316770-E039-4AC0-B980-F302ABC42A1F

P5875

Q36945144-0F5DB416-5B8C-4358-8C18-846ADF96B33F

P698

Q36945144-E5DBE3F6-6854-4EC3-98E2-11DAC1B76621

P921

Q36945144-F9BA6A73-7557-41F4-B656-2411E51E23B1

P932

Q36945144-731C93D3-71BB-47D2-9F53-B9B472D4FCD1

P356

PNAS.0808182105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Ubiquitylated PCNA plays a rol ...... uired for meiotic progression.

@en

P2093

Aviv Bergman

http://www.w3.org/2001/XMLSchema#string

Chunfang Zhao

http://www.w3.org/2001/XMLSchema#string

Elena Avdievich

http://www.w3.org/2001/XMLSchema#string

Fei Li Kuang

http://www.w3.org/2001/XMLSchema#string

Jonathan U Peled

http://www.w3.org/2001/XMLSchema#string

Matthew D Scharff

http://www.w3.org/2001/XMLSchema#string

Paula E Cohen

http://www.w3.org/2001/XMLSchema#string

Rui Kan

http://www.w3.org/2001/XMLSchema#string

Sergio Roa

http://www.w3.org/2001/XMLSchema#string

Thomas Maccarthy

http://www.w3.org/2001/XMLSchema#string

P2860

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Error rate and specificity of human and murine DNA polymerase eta

IgH class switching and translocations use a robust non-classical end-joining pathway

DNA mismatch repair: functions and mechanisms

PCNA, the maestro of the replication fork

Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

P304

16248-16253

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0808182105

http://www.w3.org/2001/XMLSchema#string

P407

P433

42

http://www.w3.org/2001/XMLSchema#string

P478

105

http://www.w3.org/2001/XMLSchema#string

P577

2008-10-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23316894

http://www.w3.org/2001/XMLSchema#string

P698

18854411

http://www.w3.org/2001/XMLSchema#string

P921

P932

2571010

http://www.w3.org/2001/XMLSchema#string