Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice - Wikidata - awgldk - TriplyDB

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

http://www.wikidata.org/entity/Q28513971

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The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system Mechanisms and functions of DNA mismatch repair Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Controlling somatic hypermutation in immunoglobulin variable and switch regions.Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.Msh6 protects mature B cells from lymphoma by preserving genomic stability.Rad9 is required for B cell proliferation and immunoglobulin class switch recombination DNA polymerases and somatic hypermutation of immunoglobulin genes Requirement for cyclin D3 in germinal center formation and function.MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Involvement of Rad18 in somatic hypermutation DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.Mechanism and regulation of class switch recombination Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta 14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.Mismatch-mediated error prone repair at the immunoglobulin genes.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.DNA deamination in immunity.14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.Does DNA repair occur during somatic hypermutation?AIDing antibody diversity by error-prone mismatch repair.Human exonuclease 1 (EXO1) activity characterization and its function on flap structures.DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair ATM is required for efficient recombination between immunoglobulin switch regions.Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions

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Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

http://www.wikidata.org/entity/Q28513971

description

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2004

@ast

im Januar 2004 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2004/02/01)

@sk

vědecký článek publikovaný v roce 2004

@cs

wetenschappelijk artikel (gepubliceerd op 2004/02/01)

@nl

наукова стаття, опублікована в лютому 2004

@uk

مقالة علمية (نشرت في فبراير 2004)

@ar

name

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@ast

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@en

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@nl

type

label

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@ast

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@en

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@nl

prefLabel

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@ast

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@en

Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

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Nature Immunology

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Altered somatic hypermutation ...... n in exonuclease 1-mutant mice

@en

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Alberto Martin

http://www.w3.org/2001/XMLSchema#string

Caroline J Woo

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Kaichun Wei

http://www.w3.org/2001/XMLSchema#string

Matthew D Scharff

http://www.w3.org/2001/XMLSchema#string

Stephen Z Sack

http://www.w3.org/2001/XMLSchema#string

Tchaiko Parris

http://www.w3.org/2001/XMLSchema#string

Winfried Edelmann

http://www.w3.org/2001/XMLSchema#string

Ziqiang Li

http://www.w3.org/2001/XMLSchema#string

P2860

The interaction of DNA mismatch repair proteins with human exonuclease I

Human exonuclease I is required for 5' and 3' mismatch repair

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.

Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.

Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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224-229

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scholarly article

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2948355

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10.1038/NI1031

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2

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5

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Philip D Bardwell

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2004-01-11T00:00:00Z

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14716311

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