Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas
about
The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemiaPreventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in ratsGenomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Salinomycin Suppresses PDGFRβ, MYC, and Notch Signaling in Human Medulloblastoma.Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.Myc roles in hematopoiesis and leukemiaCrosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specificationRedundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasmsCo-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid MalignanciesThe TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme.Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth.A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia.PTEN, stem cells, and cancer stem cellsGenomic tools for dissecting oncogenic transcriptional networks in human leukemia.Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.Leptin-promoted human extravillous trophoblast invasion is MMP14 dependent and requires the cross talk between Notch1 and PI3K/Akt signaling.EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells.Combination of RNA interference and U1 inhibition leads to increased inhibition of gene expressionNew roles for Notch in tuberous sclerosis.CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells.Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia.Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer.NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.
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Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Oncogenic NOTCH1 control of MY ...... lastic leukemias and lymphomas
@en
type
label
Oncogenic NOTCH1 control of MY ...... lastic leukemias and lymphomas
@en
prefLabel
Oncogenic NOTCH1 control of MY ...... lastic leukemias and lymphomas
@en
P2860
P1476
Oncogenic NOTCH1 control of MY ...... lastic leukemias and lymphomas
@en
P2093
Adolfo Ferrando
Teresa Palomero
P2860
P304
P356
10.1158/1078-0432.CCR-07-4864
P407
P577
2008-09-01T00:00:00Z