X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
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Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAPRas-catalyzed hydrolysis of GTP: a new perspective from model studiesIdentification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras allelesSubstrate-assisted catalysis: molecular basis and biological significanceStructure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complexGuanosine triphosphatase stimulation of oncogenic Ras mutantsTriphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanismThe conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPaseHigh resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loopNovel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffhStructural insights into a new homodimeric self-activated GTPase familyPhosphate-binding loop and Rab GTPase function: mutations at Ser29 and Ala30 of Rab5 lead to loss-of-function as well as gain-of-function phenotypeThe mechanism of GTP hydrolysis by Ras probed by Fourier transform infrared spectroscopy.Analysis of the binding surfaces of proteins.Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteriaMdr1 gene expression and mutations in Ras proto-oncogenes in acute myeloid leukemia.The biochemistry and physiology of metallic fluoride: action, mechanism, and implications.Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily.The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction siteProbing the role of loop 2 in Ras function with unnatural amino acids.Lessons from computer simulations of Ras proteins in solution and in membraneTransition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects.The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe.Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.A rab protein regulates the localization of secretory granules in AtT-20 cells.Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions.Protein Regulation in Signal Transduction.Molecular control of Rab activity by GEFs, GAPs and GDI.The Role of Gln61 in HRas GTP hydrolysis: a quantum mechanics/molecular mechanics study.Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.GTPase mechanism and function: new insights from systematic mutational analysis of the phosphate-binding loop residue Ala30 of Rab5.Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras.Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis.Revisiting the structural flexibility of the complex p21(ras)-GTP: the catalytic conformation of the molecular switch II.New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins.The Rho GTPase signalling pathway in urothelial carcinoma.
P2860
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P2860
X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
X-ray crystal structures of tr ...... mechanism for GTP hydrolysis.
@en
type
label
X-ray crystal structures of tr ...... mechanism for GTP hydrolysis.
@en
prefLabel
X-ray crystal structures of tr ...... mechanism for GTP hydrolysis.
@en
P2093
P2860
P356
P1476
X-ray crystal structures of tr ...... mechanism for GTP hydrolysis.
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.8.3649
P407
P50
P577
1992-04-01T00:00:00Z