SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
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Epigenetic determinants of metastasisSlowing ageing by design: the rise of NAD(+) and sirtuin-activating compoundsStructural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell nicheDevelopment of a radiosensitivity gene signature for patients with soft tissue sarcoma.Hmga2 translocation induced in skin tumorigenesis.Is SIRT6 Activity Neuroprotective and How Does It Differ from SIRT1 in This Regard?Cooperative down-regulation of ribosomal protein L10 and NF-κB signaling pathway is responsible for the anti-proliferative effects by DMAPT in pancreatic cancer cellsInterplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.miR-203 enhances let-7 biogenesis by targeting LIN28B to suppress tumor growth in lung cancer.SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.SIRT6: Novel Mechanisms and Links to Aging and Disease.Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway.Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma.THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin.Systematic identification of long non-coding RNAs with cancer-testis expression patterns in 14 cancer types.PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells.Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation.SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner.The role of SIRT6 in tumors.Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment.The Role of Sirt6 in Obesity and Diabetes.Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk.Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.Downregulation of SIRT6 by miR-34c-5p is associated with poor prognosis and promotes colon cancer proliferation through inhibiting apoptosis via the JAK2/STAT3 signaling pathway.SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A.TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.Structural Basis of Sirtuin 6 Activation by Synthetic Small MoleculesMetabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic TargetsPharmacological activation of SIRT6 triggers lethal autophagy in human cancer cellsHistone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity
P2860
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P2860
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
@en
type
label
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
@en
prefLabel
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
@en
P2093
P2860
P1433
P1476
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
@en
P2093
Adrianne Gladden
Alon Goren
Carlos Sebastián
Julien Fitamant
Kenneth N Ross
Kshitij S Arora
Miguel N Rivera
Nabeel Bardeesy
Raul Mostoslavsky
P2860
P304
P356
10.1016/J.CELL.2016.04.033
P407
P577
2016-05-11T00:00:00Z