Structural basis of human pregnane X receptor activation by the hops constituent colupulone
about
Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRαChallenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXRExploration of the conformational landscape in pregnane X receptor reveals a new binding pocketActivation of xenobiotic receptors: driving into the nucleus.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.Cellular localization and functional significance of CYP3A4 in the human epileptic brain.Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differentlySmall-molecule modulators of PXR and CAR.In silico investigation of agonist activity of a structurally diverse set of drugs to hPXR using HM-BSM and HM-PNN.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectiveA vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay.Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.The structural basis of pregnane X receptor binding promiscuity.Nuclear receptors in herb-drug interactions.Synthesis and P-glycoprotein induction activity of colupulone analogs.Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter products.Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases.Bioavailability of hop-derived iso-α-acids and reduced derivatives.Determination of CYP3A4 Inducing Properties of Compounds Using a Laboratory-Developed Cell-Based Assay.LASSO-ing Potential Nuclear Receptor Agonists and Antagonists: A New Computational Method for Database Screening
P2860
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P2860
Structural basis of human pregnane X receptor activation by the hops constituent colupulone
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Structural basis of human preg ...... he hops constituent colupulone
@en
type
label
Structural basis of human preg ...... he hops constituent colupulone
@en
prefLabel
Structural basis of human preg ...... he hops constituent colupulone
@en
P2093
P2860
P356
P1476
Structural basis of human preg ...... he hops constituent colupulone
@en
P2093
Denise G Teotico
Steven A Kliewer
P2860
P304
P356
10.1124/MOL.108.050732
P577
2008-09-02T00:00:00Z