The structural basis of pregnane X receptor binding promiscuity.
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Regulation of the cytosolic sulfotransferases by nuclear receptorsPregnane X receptor as a target for treatment of inflammatory bowel disordersModulation of xenobiotic receptors by steroidsActivation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptorEvaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.FTMAP: extended protein mapping with user-selected probe molecules.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARAnchoring intrinsically disordered proteins to multiple targets: lessons from N-terminus of the p53 protein.Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.Evolutionary origins of the estrogen signaling system: insights from amphioxusTranscriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its MetabolitesHot spot analysis for driving the development of hits into leads in fragment-based drug discovery.In silico investigation of agonist activity of a structurally diverse set of drugs to hPXR using HM-BSM and HM-PNN.Analysis of protein binding sites by computational solvent mapping.Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis.Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A β-Lactamases.SPA70 is a potent antagonist of human pregnane X receptor.Domain motion and interdomain hot spots in a multidomain enzymeThe role of residues T248, Y249 and T422 in the function of human pregnane X receptor.Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view.Probing ligand structure-activity relationships in pregnane X receptor (PXR): efavirenz and 8-hydroxyefavirenz exhibit divergence in activation.
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P2860
The structural basis of pregnane X receptor binding promiscuity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The structural basis of pregnane X receptor binding promiscuity.
@en
The structural basis of pregnane X receptor binding promiscuity.
@nl
type
label
The structural basis of pregnane X receptor binding promiscuity.
@en
The structural basis of pregnane X receptor binding promiscuity.
@nl
prefLabel
The structural basis of pregnane X receptor binding promiscuity.
@en
The structural basis of pregnane X receptor binding promiscuity.
@nl
P2093
P2860
P356
P1433
P1476
The structural basis of pregnane X receptor binding promiscuity.
@en
P2093
Aleksandra N Rudnitskaya
Chi-Ho Ngan
Dmitri Beglov
Sandor Vajda
P2860
P304
11572-11581
P356
10.1021/BI901578N
P407
P577
2009-12-01T00:00:00Z