FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.
about
Flk2/Flt3 promotes both myeloid and lymphoid development by expanding non-self-renewing multipotent hematopoietic progenitor cellsThe Cytokine Flt3-Ligand in Normal and Malignant HematopoiesisQuiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycleNiche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models.Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic LeukemiaLeukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish.Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.FLT3-ITD and its current role in acute myeloid leukaemia.Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis.Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in miceLoss of HIF-1α accelerates murine FLT-3(ITD)-induced myeloproliferative neoplasia.Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype.The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease
P2860
Q33720603-FEDDD21E-D028-4EB4-A28E-25A875FCDC4AQ33838356-FCD968E5-E663-4CD3-83A0-415460AB6B2CQ33849340-1B902A35-3ED0-4509-849D-C14A89F00F67Q33886530-CB85EC9A-D053-4004-82DA-3D744D5FF858Q34160912-3978F7F9-6FC3-46AD-B11A-F8BE5C1325EFQ36309953-1872473B-B3B9-4015-A6E8-4942AB486778Q36682938-2651DC84-3330-43A5-9B76-9DF4B0DD639EQ36745048-33FF6E0E-3B31-417C-B11C-9039F6091A9EQ37496355-15C87E41-B243-4E8C-9B1A-56B41340E3CDQ37599556-FDE62DC7-A448-4A36-AF98-ED7AF057AF89Q38429500-F0653DFD-7072-4C44-90BD-B9EB651BEFB3Q38951357-85952D90-9ED3-41DF-BB4F-BAAA71E18E40Q39169246-3DB7B2A3-AAC0-4AD0-BD54-BA63D6E999D7Q39282600-3273058C-9A49-447E-A79F-FD652325E46AQ40293334-63C7BC08-5EE4-48E9-B5D1-6D9F4C758146Q40832501-E5887A96-4B2C-4B09-BA69-82112811C60AQ41866413-01137BA5-5922-4B31-B160-5228B1ED6349Q42391590-F349D01C-BA87-4A02-A427-9772EBF74A60Q45877127-47FEA9F1-929E-4F08-B472-583C6E2C4D89Q53129470-30B56DF6-CB84-4352-ACFC-435D27E3C880Q58699279-70C205F7-C5D6-4211-932D-80D438F9575E
P2860
FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
FLT3-ITDs instruct a myeloid d ...... eloid multipotent progenitors.
@en
type
label
FLT3-ITDs instruct a myeloid d ...... eloid multipotent progenitors.
@en
prefLabel
FLT3-ITDs instruct a myeloid d ...... eloid multipotent progenitors.
@en
P2093
P2860
P50
P1433
P1476
FLT3-ITDs instruct a myeloid d ...... eloid multipotent progenitors.
@en
P2093
Christian Pecquet
Claus Nerlov
Deborah Atkinson
Ewa Sitnicka
Helen Ferry
Michael Lutteropp
Natalija Buza-Vidas
Nicolas Goardon
Onima Chowdhury
Petter Woll
P2860
P304
P356
10.1016/J.CELREP.2013.04.031
P577
2013-05-30T00:00:00Z