Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging.
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Methods to Increase the Metabolic Stability of (18)F-RadiotracersPopulation-based input function modeling for [(18)F]FMPEP-d 2, an inverse agonist radioligand for cannabinoid CB1 receptors: validation in clinical studiesPET radiotracers: crossing the blood-brain barrier and surviving metabolismBiodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography.Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers.[¹²⁵I]SD-7015 reveals fine modalities of CB₁ cannabinoid receptor density in the prefrontal cortex during progression of Alzheimer's diseaseIn vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse.Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands.N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptorsDecreased defluorination using the novel beta-cell imaging agent [18F]FE-DTBZ-d4 in pigs examined by PETBinding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophreniaA PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates.Enhanced radiosyntheses of [¹¹C]raclopride and [¹¹C]DASB using ethanolic loop chemistry.Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier isotopologues.Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography.On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human.Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand.Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors.Synthetic strategies for radioligands for in vivo imaging of brain cannabinoid type-1 receptors.Automated synthesis and purification of [18F]fluoro-[di-deutero]methyl tosylate.Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications.From racemic precursors to fully stereocontrolled products: one-pot synthesis of chiral α-amino lactones and lactams.
P2860
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P2860
Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Synthesis, ex vivo evaluation, ...... andidates for in vivo imaging.
@en
type
label
Synthesis, ex vivo evaluation, ...... andidates for in vivo imaging.
@en
prefLabel
Synthesis, ex vivo evaluation, ...... andidates for in vivo imaging.
@en
P2093
P2860
P921
P356
P1476
Synthesis, ex vivo evaluation, ...... andidates for in vivo imaging.
@en
P2093
Amy K Chesterfield
Christian C Felder
Eyassu Chernet
John M Schaus
Joseph H Krushinski
Lee Phebus
Sean R Donohue
Victor W Pike
P2860
P304
P356
10.1021/JM800416M
P407
P577
2008-09-01T00:00:00Z