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Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nucleaseZinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cellsHybrid restriction enzymes: zinc finger fusions to Fok I cleavage domainTAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domainStructure of FokI has implications for DNA cleavageProtein assembly and DNA looping by the FokI restriction endonuclease.Genome-editing Technologies for Gene and Cell TherapyOrigins of Programmable Nucleases for Genome EngineeringEnabling functional genomics with genome engineeringCCR5 Targeted Cell Therapy for HIV and Prevention of Viral EscapeRewriting the blueprint of life by synthetic genomics and genome engineeringStructure of the multimodular endonuclease FokI bound to DNACreating designed zinc-finger nucleases with minimal cytotoxicityGenome Engineering With Zinc-Finger NucleasesIn vitro selection of restriction endonucleases by in vitro compartmentalizationChimeric restriction enzymes: what is next?The I-TevI nuclease and linker domains contribute to the specificity of monomeric TALENsType II restriction endonucleases--a historical perspective and moreR2 target-primed reverse transcription: ordered cleavage and polymerization steps by protein subunits asymmetrically bound to the target DNA.The nicking endonuclease N.BstNBI is closely related to type IIs restriction endonucleases MlyI and PleIEngineering a nicking endonuclease N.AlwI by domain swapping.Zebrafish Genome Engineering Using the CRISPR-Cas9 System.Custom-designed zinc finger nucleases: what is next?Many type IIs restriction endonucleases interact with two recognition sites before cleaving DNA.Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavageComparative characterization of the PvuRts1I family of restriction enzymes and their application in mapping genomic 5-hydroxymethylcytosineExpression and purification of a single-chain Type IV restriction enzyme Eco94GmrSD and determination of its substrate preference.Rapid prototyping of microbial cell factories via genome-scale engineering.Hydrogen Peroxide Induce Human Cytomegalovirus Replication through the Activation of p38-MAPK Signaling Pathway.The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells.Alteration of the cleavage distance of Fok I restriction endonuclease by insertion mutagenesis.Targeting a SWI/SNF-related chromatin remodeling complex to the beta-globin promoter in erythroid cells.Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fok I endonuclease.Construction of a Z-DNA-specific restriction endonuclease.An EM view of the FokI synaptic complex by single particle analysisAn alternative novel tool for DNA editing without target sequence limitation: the structure-guided nucleaseChimeric restriction endonuclease.Intron-encoded endonuclease I-TevI binds as a monomer to effect sequential cleavage via conformational changes in the td homing site.The reaction mechanism of FokI excludes the possibility of targeting zinc finger nucleases to unique DNA sites.Are genes switched on when they kiss?
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Functional domains in Fok I restriction endonuclease.
@en
Functional domains in Fok I restriction endonuclease.
@nl
type
label
Functional domains in Fok I restriction endonuclease.
@en
Functional domains in Fok I restriction endonuclease.
@nl
prefLabel
Functional domains in Fok I restriction endonuclease.
@en
Functional domains in Fok I restriction endonuclease.
@nl
P2860
P356
P1476
Functional domains in Fok I restriction endonuclease
@en
P2093
S Chandrasegaran
P2860
P304
P356
10.1073/PNAS.89.10.4275
P407
P50
P577
1992-05-01T00:00:00Z