about
Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cellsHybrid restriction enzymes: zinc finger fusions to Fok I cleavage domainZinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleasesTAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domainFokI dimerization is required for DNA cleavageStructure of FokI has implications for DNA cleavageGeneration of DNA cleavage specificities of type II restriction endonucleases by reassortment of target recognition domainsCatalytic domain of restriction endonuclease BmrI as a cleavage module for engineering endonucleases with novel substrate specificitiesRestriction endonuclease BpuJI specific for the 5'-CCCGT sequence is related to the archaeal Holliday junction resolvase familyDeveloping a programmed restriction endonuclease for highly specific DNA cleavageGenome-editing Technologies for Gene and Cell TherapyOrigins of Programmable Nucleases for Genome EngineeringFrom Gene Targeting to Genome Editing: Transgenic animals applications and beyondRewriting the blueprint of life by synthetic genomics and genome engineeringStructure of the multimodular endonuclease FokI bound to DNACRISPR-Cas9: from Genome Editing to Cancer ResearchGene targeting using zinc finger nucleasesCreating designed zinc-finger nucleases with minimal cytotoxicityOligo/polynucleotide-based gene modification: strategies and therapeutic potentialGenome Engineering With Zinc-Finger NucleasesRelated bifunctional restriction endonuclease-methyltransferase triplets: TspDTI, Tth111II/TthHB27I and TsoI with distinct specificities.In vitro selection of restriction endonucleases by in vitro compartmentalizationImproved assays for determining the cytosolic access of peptides, proteins, and their mimetics.Zinc finger nucleases as tools to understand and treat human diseases.Chimeric restriction enzymes: what is next?Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domainsModification of the substrate specificity of an acyl-acyl carrier protein thioesterase by protein engineering.Stimulation of homologous recombination through targeted cleavage by chimeric nucleases.Engineering a nicking endonuclease N.AlwI by domain swapping.Enzymatic synthesis of long double-stranded DNA labeled with haloderivatives of nucleobases in a precisely pre-determined sequence.Custom-designed zinc finger nucleases: what is next?Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavageLarge chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice.Studying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT)The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells.Targeted gene knockout by direct delivery of zinc-finger nuclease proteins.Construction of a Z-DNA-specific restriction endonuclease.Evolution of sequence specificity in a restriction endonuclease by a point mutationUsing homologous recombination to manipulate the genome of human somatic cells.An EM view of the FokI synaptic complex by single particle analysis
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1994
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Chimeric restriction endonuclease.
@en
Chimeric restriction endonuclease.
@nl
type
label
Chimeric restriction endonuclease.
@en
Chimeric restriction endonuclease.
@nl
prefLabel
Chimeric restriction endonuclease.
@en
Chimeric restriction endonuclease.
@nl
P2860
P356
P1476
Chimeric restriction endonuclease.
@en
P2093
S Chandrasegaran
P2860
P304
P356
10.1073/PNAS.91.3.883
P407
P577
1994-02-01T00:00:00Z