Trisomy 21 enhances human fetal erythro-megakaryocytic development. - Wikidata - awgldk - TriplyDB

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

http://www.wikidata.org/entity/Q37001957

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The biology of pediatric acute megakaryoblastic leukemia Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells Prognosis and management of acute myeloid leukemia in patients with Down syndrome Myeloid leukemia in Down syndrome A System to Study Aneuploidy In Vivo miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy.Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder.Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.Down syndrome and malignancies: a unique clinical relationship: a paper from the 2008 william beaumont hospital symposium on molecular pathology Down syndrome--recent progress and future prospects.GATA Transcription Factors and Cancer.Integrated differential transcriptome maps of Acute Megakaryoblastic Leukemia (AMKL) in children with or without Down Syndrome (DS)MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells.Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21 Myeloid Proliferations Associated with Down Syndrome.Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.Trisomy correction in Down syndrome induced pluripotent stem cells.Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder Constitutional aneuploidy and cancer predisposition.Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes.GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.Unique clinical and biological features of leukemia in Down syndrome children.Mouse models of diseases of megakaryocyte and platelet homeostasis.Prospects and challenges of reprogrammed cells in hematology and oncology.The impact of trisomy 21 on foetal haematopoiesis.Transient myeloproliferative disorder in neonates without Down syndrome: case report and review.Haematopoietic development and leukaemia in Down syndrome.Stem and progenitor cell dysfunction in human trisomies.

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P2860

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

http://www.wikidata.org/entity/Q37001957

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article científic

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artigo científico

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bilimsel makale

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scientific article published on 23 September 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

@en

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

@nl

type

label

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

@en

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

@nl

prefLabel

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

@en

Trisomy 21 enhances human fetal erythro-megakaryocytic development.

@nl

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BLOOD-2008-05-157859

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Trisomy 21 enhances human fetal erythro-megakaryocytic development.

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Alan M Gewirtz

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Anna Kalota

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Gwenn-ael Danet-Desnoyers

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Joanna B Opalinska

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John K Choi

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John S J Brooks

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Mitchell J Weiss

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Myriam A Fernandes

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Richard L Nemiroff

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Stella T Chou

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P2860

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21

Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

GATA1 in normal and malignant hematopoiesis

Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome

The management of neoplastic disorders of haematopoiesis in children with Down's syndrome.

Prospective isolation of human clonogenic common myeloid progenitors.

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.

The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor.

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4503-4506

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10.1182/BLOOD-2008-05-157859

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23277505

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18812473

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