Cysteine cathepsin proteases as pharmacological targets in cancer.
about
Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activityMolecular functions of thyroid hormones and their clinical significance in liver-related diseasesCathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cellsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateThe role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cellsEmerging role of mast cells and macrophages in cardiovascular and metabolic diseasesCysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probesThe lysosome: from waste bag to potential therapeutic targetHemopressin and other bioactive peptides from cytosolic proteins: are these non-classical neuropeptides?Inhibitor of cysteine proteases is critical for motility and infectivity of Plasmodium sporozoitesOptical imaging probes in oncologyToward precision medicine of breast cancerRedox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moietyMicroscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activityTopical application of activity-based probes for visualization of brain tumor tissueA comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinomaCathepsin K inhibitors for osteoporosis and potential off-target effectsWhy don't we get more cancer? A proposed role of the microenvironment in restraining cancer progressionCathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration.Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment.Systematic optimization of multiplex zymography protocol to detect active cathepsins K, L, S, and V in healthy and diseased tissue: compromise among limits of detection, reduced time, and resources.Monitoring peptidase activities in complex proteomes by MALDI-TOF mass spectrometryIL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sitesSynthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L.Light activation of a cysteine protease inhibitor: caging of a peptidomimetic nitrile with Ru(II)(bpy)2Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.Aminopeptidase activities as prospective urinary biomarkers for bladder cancer.How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamicsInhibition of cathepsin activity in a cell-based assay by a light-activated ruthenium compound.A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.Functional protease profiling for diagnosis of malignant disease.Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors.Droplet electrospray ionization mass spectrometry for high throughput screening for enzyme inhibitorsDistinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.Emerging principles in protease-based drug discovery.Pericellular proteolysis in cancerInhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin SAlternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions.
P2860
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P2860
Cysteine cathepsin proteases as pharmacological targets in cancer.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Cysteine cathepsin proteases as pharmacological targets in cancer.
@en
Cysteine cathepsin proteases as pharmacological targets in cancer.
@nl
type
label
Cysteine cathepsin proteases as pharmacological targets in cancer.
@en
Cysteine cathepsin proteases as pharmacological targets in cancer.
@nl
prefLabel
Cysteine cathepsin proteases as pharmacological targets in cancer.
@en
Cysteine cathepsin proteases as pharmacological targets in cancer.
@nl
P1476
Cysteine cathepsin proteases as pharmacological targets in cancer.
@en
P2093
Carmela Palermo
Johanna A Joyce
P356
10.1016/J.TIPS.2007.10.011
P577
2007-11-26T00:00:00Z