A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. - Wikidata - awgldk - TriplyDB

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.

http://www.wikidata.org/entity/Q37023129

about

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase Cancer/Testis Antigen PASD1 Silences the Circadian Clock Circadian rhythms persist without transcription in a eukaryote A genome-wide RNAi screen for modifiers of the circadian clock in human cells Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health Review of pharmacological treatment in mood disorders and future directions for drug development.Pharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapy Circadian clock control of endocrine factors CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock Chemical chronobiology: Toward drugs manipulating time.CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism Emerging models for the molecular basis of mammalian circadian timing Metabolism as an integral cog in the mammalian circadian clockwork DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons Profile of Steve Kay.GSK-3: Functional Insights from Cell Biology and Animal Models.Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.Circadian rhythms and metabolic syndrome: from experimental genetics to human disease.Effect of aripiprazole on non-24-hour sleep-wake rhythm disorder comorbid with major depressive disorder: a case report.Circadian control of glucose metabolism.A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation Circadian clocks and metabolism.Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases.PubChem's BioAssay Database.Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response.Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana.Lithium impacts on the amplitude and period of the molecular circadian clockwork.Mammalian molecular clocks.Mammalian circadian clock and metabolism - the epigenetic link Speed control: cogs and gears that drive the circadian clock.Identification of small molecule activators of cryptochrome Genomics and systems approaches in the mammalian circadian clock Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.Small molecule modifiers of circadian clocks.Systems Biology-Derived Discoveries of Intrinsic Clocks.

P2860

Q21563543-E22366EA-AA57-4364-A6F0-029626AB2FF8 Q24337215-7D266DBE-DB0F-4498-96CD-0FE54691D4C8 Q24620683-FD809F51-32AE-42EA-A3E4-5B4BBDD7BCF2 Q24655808-B77DD88D-54B2-4928-89EC-04F4536F9D91 Q26765492-BE286EED-BD60-4AF5-9E8A-E61164F54AD1 Q26853509-18AA2EF6-791E-4CDB-BD03-C68C9EA90787 Q26864230-BF6B6B4E-5ED4-4CAA-97FE-8FFF86D0F07D Q27022325-94B77D08-5D38-4927-9431-2AF3B6DE775E Q27346393-66AD9860-87EB-4D34-9FEE-DAD015FCA294 Q27687867-D88F6DB6-C236-4122-992E-4BFB0DA16644 Q27865241-54372FB7-ACCA-4A8D-90B8-743C331CD294 Q27865249-6E25E718-CB21-45C5-A6B2-FBF1BBE0C97E Q28249506-F7DAEFB9-61DE-45A5-9AFD-F11CA9A7268D Q28392866-D15155C1-CF13-4C7D-A034-9B42F4CDBBAC Q28512443-8AA1D64E-AA53-47AA-9016-3B4BB6D0FAA2 Q28541855-45600972-DB53-46BB-839D-DD3BAD14391F Q28552603-1B6BF802-927E-4B59-A75F-0000E0E55CD8 Q30436364-E6B52DFE-4B3E-4CE6-9C99-B5C15CE8F8A6 Q30472813-91C2E4FF-A1D5-4869-B163-AEC2B431F1B5 Q33521907-DF481EBC-A574-4504-8176-845ACC4815AD Q33652788-097B0F8A-C10F-4E87-9654-51948470B238 Q33722806-30D496AB-F405-4403-A441-066810B515B8 Q33739852-3B88BDBD-1914-4508-AED4-651AC0F7E130 Q33766028-788FD040-0AF0-45D5-8243-928940758AB6 Q33815603-CDAFB1C1-D83A-4889-9FFF-1D45A0F7ACAA Q33871157-866CC1E4-ECC8-40D5-BD1E-4A399E0CC2BE Q34069133-F4482E35-3930-440C-BA05-D17E5FE1BF40 Q34090643-C64D9E1D-1840-4009-8E5A-3BC809FCADB9 Q34128870-A6406F9D-5C45-4205-B3DE-D9095C1DDEB5 Q34182250-DBF0239B-89B4-4288-AF72-767F31CDC6BB Q34191772-1B19C84F-0CED-4525-A014-0E0389C9DDC8 Q34200717-848D5416-E435-4EC0-8B49-8544099D0F90 Q34235388-0DAE002E-F412-4266-A32D-108BDCEED14C Q34273678-C30D2DAF-5846-4876-846D-45C606D2C067 Q34285136-6787EAC6-A5A5-4F54-B7CE-A1FAE8145342 Q34288305-17252270-ABD4-41C7-A57B-963B98678DA9 Q34316534-709FA517-12E2-4496-B65A-2A9CC7EFEC5C Q34326979-AA45B5CB-87E0-4EC9-A4D7-9D2D0B83AAEE Q34480532-F503AAFB-F956-4FFB-863F-3051035BB98F Q34551665-B7DAD711-DED8-4056-895F-B8BD487DBA87

P2860

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.

http://www.wikidata.org/entity/Q37023129

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 22 December 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

A chemical biology approach re ...... cific inhibition of GSK-3beta.

@en

A chemical biology approach re ...... cific inhibition of GSK-3beta.

@nl

type

label

A chemical biology approach re ...... cific inhibition of GSK-3beta.

@en

A chemical biology approach re ...... cific inhibition of GSK-3beta.

@nl

prefLabel

A chemical biology approach re ...... cific inhibition of GSK-3beta.

@en

A chemical biology approach re ...... cific inhibition of GSK-3beta.

@nl

P1433

Q37023129-857BE853-A093-49D7-B222-E9339D1E4D1D

P1476

Q37023129-E6A1A772-25F5-4A34-9CA7-C609CBDE21E7

P2093

Q37023129-1B128378-AF1A-4B6D-8F5F-EF9B96AC87DD

Q37023129-4CAA798D-E9D4-4EEB-AC92-8D7D3058083F

Q37023129-8CE596EA-0B20-46C2-8F1E-CF132A6EEE1B

Q37023129-AAFF55B2-663E-4DB5-A7A5-CC8194C2226A

Q37023129-BA456FA7-E654-4236-B6E9-0CB5E536CAB3

Q37023129-CA256E18-DAA0-4F77-8BC5-B7E044143666

P2860

Q37023129-0E389B1C-294D-4B47-A7F8-6A0B573D8F6A

Q37023129-13BFE438-9989-467B-9546-6BD60FACB3C2

Q37023129-1A7C521E-7AD5-466E-BCC0-6A6E87F5B223

Q37023129-34F7B580-BCB4-4CC1-B768-243FB1EFA2E7

Q37023129-3AF14644-33B3-467B-B69E-EE7DFC0F474F

Q37023129-3C09F0BD-C294-413D-9BE4-EACDF885EDAD

Q37023129-4B8554BC-0A14-42A8-9238-AAF93B3F096C

Q37023129-50023C4C-CD3B-4818-92C8-E88BA76CDD7C

Q37023129-52E9032A-7CE8-4BC3-8F36-60814B4AD8AE

Q37023129-5A69B3EB-2D6E-4D8D-87AB-4FA6AB032C29

P304

Q37023129-19CB9114-0B15-4534-AEB9-618167BED98A

P31

Q37023129-1922F934-8EDD-4522-99D2-254BD25C5F8E

P356

Q37023129-37820151-A54F-4FF0-8618-F012593D62CD

P407

Q37023129-EEB29BB3-E4A9-4698-A5AF-89BB79019B88

P433

Q37023129-12585C5F-7AE4-44F3-8054-9F67CCECA717

P478

Q37023129-69780DB3-3AE7-41F5-812C-A035E77C981E

P577

Q37023129-3878C8FB-50FE-49CF-9A60-53E551BADFC6

P5875

Q37023129-01AC3531-6A80-42A2-B0DD-1F27C8D7F4CD

P698

Q37023129-16C713E3-091F-480B-851F-8B1ED95EAECD

P921

Q37023129-D7E5A8AA-1C17-42B7-A129-E417593FF228

P932

Q37023129-7856D5D5-DAF4-4007-BB2C-738D262F3E69

P356

PNAS.0811410106

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

A chemical biology approach re ...... cific inhibition of GSK-3beta.

@en

P2093

Andrew C Liu

http://www.w3.org/2001/XMLSchema#string

Jae Wook Lee

http://www.w3.org/2001/XMLSchema#string

Peter G Schultz

http://www.w3.org/2001/XMLSchema#string

Steve A Kay

http://www.w3.org/2001/XMLSchema#string

Tsuyoshi Hirota

http://www.w3.org/2001/XMLSchema#string

Warren G Lewis

http://www.w3.org/2001/XMLSchema#string

P2860

Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Coordination of circadian timing in mammals

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.

Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.

A time-less function for mouse timeless

Time zones: a comparative genetics of circadian clocks

A role for casein kinase 2alpha in the Drosophila circadian clock

The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

P304

20746-20751

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0811410106

http://www.w3.org/2001/XMLSchema#string

P407

P433

52

http://www.w3.org/2001/XMLSchema#string

P478

105

http://www.w3.org/2001/XMLSchema#string

P577

2008-12-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23685650

http://www.w3.org/2001/XMLSchema#string

P698

19104043

http://www.w3.org/2001/XMLSchema#string

P921

circadian rhythm

P932

2606900

http://www.w3.org/2001/XMLSchema#string