Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo
about
Increased nuclear factor 1 binding to its nucleosomal site mediated by sequence-dependent DNA structureCloning and characterization of HuR, a ubiquitously expressed Elav-like proteinExpression and characterization of recombinant caveolin. Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranesDioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene transcriptionMechanism of dioxin action: receptor-enhancer interactions in intact cellsNuclear factor 1 is required for both hormone-dependent chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter.Aryl hydrocarbon-induced interactions at multiple DNA elements of diverse sequence--a multicomponent mechanism for activation of cytochrome P4501A1 (CYP1A1) gene transcription.The mechanism of dioxin toxicity: relationship to risk assessmentThe aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxinTransactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo.Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters.NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoterNuclear factor-1 and metal transcription factor-1 synergistically activate the mouse metallothionein-1 gene in response to metal ions.Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element.Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure.Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer.Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site.Aryl hydrocarbon receptor-mediated signal transduction.Comparison of CYP1A1 induction and genotoxicity in vitro as indicators of potentially harmful effects of environmental samples.Induction of drug-metabolizing enzymes by dioxin.Transcriptional activation by the mouse Ah receptor. Interplay between multiple stimulatory and inhibitory functions.Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses.Phenobarbital alters protein binding to the CYP2B1/2 phenobarbital-responsive unit in native chromatin.Aryl Hydrocarbon Receptor Diet and Breast Cancer Risk.
P2860
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P2860
Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1992
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mechanism of dioxin action: Ah ...... promoter accessibility in vivo
@en
Mechanism of dioxin action: Ah ...... romoter accessibility in vivo.
@nl
type
label
Mechanism of dioxin action: Ah ...... promoter accessibility in vivo
@en
Mechanism of dioxin action: Ah ...... romoter accessibility in vivo.
@nl
prefLabel
Mechanism of dioxin action: Ah ...... promoter accessibility in vivo
@en
Mechanism of dioxin action: Ah ...... romoter accessibility in vivo.
@nl
P2860
P356
P1476
Mechanism of dioxin action: Ah ...... promoter accessibility in vivo
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.11.4811
P407
P577
1992-06-01T00:00:00Z