Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. - Wikidata - awgldk - TriplyDB

Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts.

Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts.

http://www.wikidata.org/entity/Q37036908

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β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma Identifying and targeting tumor-initiating cells in the treatment of breast cancer β1 and β4 integrins: from breast development to clinical practice A computer-assisted 3D model for analyzing the aggregation of tumorigenic cells reveals specialized behaviors and unique cell types that facilitate aggregate coalescence The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy Coadministration of the FNIII14 Peptide Synergistically Augments the Anti-Cancer Activity of Chemotherapeutic Drugs by Activating Pro-Apoptotic Bim Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance Controlled breast cancer microarrays for the deconvolution of cellular multilayering and density effects upon drug responses High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.Miniaturized pre-clinical cancer models as research and diagnostic tools.Integrins in development and cancer.Microenvironmental regulation of therapeutic response in cancer Integration of biological knowledge and gene expression data for biomarker selection: FN1 as a potential predictor of radiation resistance in head and neck cancer.Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.Fibroblast heterogeneity in the cancer wound.PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha RAD9 enhances radioresistance of human prostate cancer cells through regulation of ITGB1 protein levels.beta1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin.HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment.Cell-matrix interactions in mammary gland development and breast cancer Genome-wide gene expression analysis in cancer cells reveals 3D growth to affect ECM and processes associated with cell adhesion but not DNA repair.The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells.Somatic mutations favorable to patient survival are predominant in ovarian carcinomas Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.A cell-ECM screening method to predict breast cancer metastasis.Metastasis Update: Human Prostate Carcinoma Invasion via Tubulogenesis.β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib.β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer.Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced.3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response.Focal adhesion-chromatin linkage controls tumor cell resistance to radio- and chemotherapy Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.The mesenchymal tumor microenvironment: a drug-resistant niche.Expression of ITGB1 predicts prognosis in colorectal cancer: a large prospective study based on tissue microarray Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells.

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Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts.

http://www.wikidata.org/entity/Q37036908

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on June 2008

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Beta1 integrin inhibition dram ...... uman breast cancer xenografts.

@en

Beta1 integrin inhibition dram ...... uman breast cancer xenografts.

@nl

type

label

Beta1 integrin inhibition dram ...... uman breast cancer xenografts.

@en

Beta1 integrin inhibition dram ...... uman breast cancer xenografts.

@nl

prefLabel

Beta1 integrin inhibition dram ...... uman breast cancer xenografts.

@en

Beta1 integrin inhibition dram ...... uman breast cancer xenografts.

@nl

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0008-5472.CAN-07-6390

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Cancer Research

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Beta1 integrin inhibition dram ...... uman breast cancer xenografts.

@en

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Catherine C Park

http://www.w3.org/2001/XMLSchema#string

Chong J Park

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Evelyn S Yao

http://www.w3.org/2001/XMLSchema#string

Hui J Zhang

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Mina J Bissell

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P2860

Ionizing radiation induces heritable disruption of epithelial cell interactions

Integrins: bidirectional, allosteric signaling machines

Integrin signaling

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

Ionizing radiation induces up-regulation of functional beta1-integrin in human lung tumour cell lines in vitro.

Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels.

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment.

Radiation and the microenvironment - tumorigenesis and therapy.

Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PC12): evidence that they function as alpha/beta heterodimeric receptors for laminin and type IV collagen.

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4398-4405

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scholarly article

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10.1158/0008-5472.CAN-07-6390

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P433

11

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68

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2008-06-01T00:00:00Z

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51396294

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P698

18519702

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P921

radiation therapy

P932

3719863

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