Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysSuperoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialRational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsAn educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways.A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itselfPharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 miceDifferential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorSuperoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.Simple biological systems for assessing the activity of superoxide dismutase mimics.Manganese superoxide dismutase, MnSOD and its mimicsDesign, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles.Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide.Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain.Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes.High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coliDetermination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics.Acid-base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins: voltammetric and chronocoulometric study of protolytic and redox equilibria.Thermal stability of the prototypical Mn porphyrin-based superoxide dismutase mimic and potent oxidative-stress redox modulator Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin chloride, MnTE-2-PyP(5+).Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.
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Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 May 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Impact of electrostatics in re ...... orphyrin acts as a Mn carrier.
@en
Impact of electrostatics in re ...... orphyrin acts as a Mn carrier.
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type
label
Impact of electrostatics in re ...... orphyrin acts as a Mn carrier.
@en
Impact of electrostatics in re ...... orphyrin acts as a Mn carrier.
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prefLabel
Impact of electrostatics in re ...... orphyrin acts as a Mn carrier.
@en
Impact of electrostatics in re ...... orphyrin acts as a Mn carrier.
@nl
P2093
P2860
P50
P1476
Impact of electrostatics in re ...... porphyrin acts as a Mn carrier
@en
P2093
Ines Batinić-Haberle
Ivan Spasojević
Ynara M Idemori
P2860
P304
P356
10.1016/J.FREERADBIOMED.2008.04.009
P577
2008-05-05T00:00:00Z