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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksDVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damageImbalances in p97 co-factor interactions in human proteinopathyUBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnoverThe ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substratesSVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagyThe tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteinsSignal-peptide-mediated translocation is regulated by a p97-AIRAPL complexStructure and Function of the PLAA/Ufd3-p97/Cdc48 ComplexThe Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97A stress-responsive system for mitochondrial protein degradationRlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturationSignal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97.UBXD Proteins: A Family of Proteins with Diverse Functions in CancerThe general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactorsControl of p97 function by cofactor bindingStructural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated DegradationWss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugatesSystematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domainsA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.The final moments of misfolded proteins en route to the proteasome.The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain.Nucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal region.The complexities of p97 function in health and diseaseDistinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyThe ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment.Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex.The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD)Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPaseValosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal.Role of p97/VCP (Cdc48) in genome stability.
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Insights into adaptor binding to the AAA protein p97.
@en
Insights into adaptor binding to the AAA protein p97.
@nl
type
label
Insights into adaptor binding to the AAA protein p97.
@en
Insights into adaptor binding to the AAA protein p97.
@nl
prefLabel
Insights into adaptor binding to the AAA protein p97.
@en
Insights into adaptor binding to the AAA protein p97.
@nl
P2093
P50
P356
P1476
Insights into adaptor binding to the AAA protein p97.
@en
P2093
Hajime Niwa
Heidi O Yeung
Patrik Kloppsteck
P356
10.1042/BST0360062
P577
2008-02-01T00:00:00Z