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A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.Modulation of CFTR gating by permeant ions.Localizing a gate in CFTR.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeationSpatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathwayAcute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.Functional architecture of the CFTR chloride channel.Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.Electrostatic tuning of the pre- and post-hydrolytic open states in CFTRArchitecture and functional properties of the CFTR channel pore.Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator.The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.CFTR potentiators: from bench to bedside.Structural mechanisms of CFTR function and dysfunction.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Nonequilibrium gating of CFTR on an equilibrium theme.
@en
Nonequilibrium gating of CFTR on an equilibrium theme.
@nl
type
label
Nonequilibrium gating of CFTR on an equilibrium theme.
@en
Nonequilibrium gating of CFTR on an equilibrium theme.
@nl
prefLabel
Nonequilibrium gating of CFTR on an equilibrium theme.
@en
Nonequilibrium gating of CFTR on an equilibrium theme.
@nl
P2860
P1433
P1476
Nonequilibrium gating of CFTR on an equilibrium theme.
@en
P2093
Kang-Yang Jih
Tzyh-Chang Hwang
P2860
P304
P356
10.1152/PHYSIOL.00026.2012
P577
2012-12-01T00:00:00Z