Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation
about
Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.Modulation of CFTR gating by permeant ions.Localizing a gate in CFTR.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Molecular modelling and molecular dynamics of CFTR.Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulatorSpatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathwayFunctional architecture of the CFTR chloride channel.Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.Cytoplasmic pathway followed by chloride ions to enter the CFTR channel pore.Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.Electrostatic tuning of the pre- and post-hydrolytic open states in CFTRInteraction between 2 extracellular loops influences the activity of the cystic fibrosis transmembrane conductance regulator chloride channel.Architecture and functional properties of the CFTR channel pore.Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS.Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.Relative contribution of different transmembrane segments to the CFTR chloride channel pore.External Zn(2+) binding to cysteine-substituted cystic fibrosis transmembrane conductance regulator constructs regulates channel gating and curcumin potentiation.Stoichiometry and novel gating mechanism within the cystic fibrosis transmembrane conductance regulator channel.Structural mechanisms of CFTR function and dysfunction.
P2860
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P2860
Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Cysteine scanning of CFTR's fi ...... roles in gating and permeation
@ast
Cysteine scanning of CFTR's fi ...... roles in gating and permeation
@en
type
label
Cysteine scanning of CFTR's fi ...... roles in gating and permeation
@ast
Cysteine scanning of CFTR's fi ...... roles in gating and permeation
@en
prefLabel
Cysteine scanning of CFTR's fi ...... roles in gating and permeation
@ast
Cysteine scanning of CFTR's fi ...... roles in gating and permeation
@en
P2093
P2860
P1433
P1476
Cysteine scanning of CFTR's fi ...... roles in gating and permeation
@en
P2093
Tzyh-Chang Hwang
Xiaolong Gao
Yonghong Bai
P2860
P304
P356
10.1016/J.BPJ.2012.12.048
P407
P577
2013-02-01T00:00:00Z